Effects of Collagen Hydrolysates on Human Brain Structure and Cognitive Function: A Pilot Clinical Study
Effects of Collagen Hydrolysates on Human Brain Structure and Cognitive Function: A Pilot Clinical Study
复制标题
DOI：
10.3390/nu12010050
复制
发表时间：
2020-01-01
期刊：
影响因子：
5.9
通讯作者：
Igase, Michiya
中科院分区：
文献类型：
--
作者：
Koizumi, Seiko;Inoue, Naoki;Igase, Michiya
本研究探讨了胶原蛋白水解物（CH）对语言认知功能和脑结构的影响。在这项开放标签研究中，30名49-63岁的健康受试者每天一次服用5 g CH，持续4周。主要结局指标为基于灰质体积（GM-BHQ）和各向异性分数（FA-BHQ）的脑健康状况。次要结局指标为第0周至第4周的单词列表记忆（WLM）和标准言语配对联想学习（S-PA）测试评分的变化，以及SF-36生活质量量表的生理、心理和角色/社会成分总分的变化。CH摄入导致FA-BHQ（p = 0.0095）（一种大脑结构的测量）以及WLM（p = 0.0046）和S-PA（p = 0.0007）测试（测量认知功能）的得分显著改善。WLM评分变化与GM-BHQ变化之间存在中度相关性（r = 0.4448;斯皮尔曼等级相关），S-PA评分变化与FA-BHQ变化之间存在中度相关性（r = 0.4645）。每天摄入CH改变了大脑结构，改善了语言认知功能。
This study investigated the effects of collagen hydrolysates (CH) on language cognitive function and brain structure. In this open-label study, 5 g CH was administered once a day for 4 weeks to 30 healthy participants aged 49-63 years. The primary outcome measures were the brain healthcare quotients based on gray matter volume (GM-BHQ) and fractional anisotropy (FA-BHQ). The secondary outcome measures were changes in scores between week 0 and week 4 for word list memory (WLM) and standard verbal paired associate learning (S-PA) tests as well as changes in the physical, mental, and role/social component summary scores of the Short Form-36(SF-36) quality of life instrument. CH ingestion resulted in significant improvements in FA-BHQ (p = 0.0095), a measure of brain structure, as well in scores for the WLM (p = 0.0046) and S-PA (p = 0.0007) tests, which measure cognitive function. There were moderate correlations between the change in WLM score and the change in GM-BHQ (r = 0.4448; Spearman's rank correlation) and between the change in S-PA score and the change in FA-BHQ (r = 0.4645). Daily ingestion of CH changed brain structure and improved language cognitive function.