Masculinizing Effect of Dihydrotestosterone on Growth Hormone Secretion is Inhibited in Ovariectomized Rats with Anterolateral Deafferentation of the Medial Basal Hypothalamus or in Intact Female Rats
Masculinizing Effect of Dihydrotestosterone on Growth Hormone Secretion is Inhibited in Ovariectomized Rats with Anterolateral Deafferentation of the Medial Basal Hypothalamus or in Intact Female Rats
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双氢睾酮对内侧基底下丘脑前外侧传入神经阻滞的卵巢切除大鼠或完整雌性大鼠生长激素分泌的雄性化作用受到抑制
DOI：
10.1046/j.1365-2826.2000.00465.x
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发表时间：
2000
影响因子：
3.2
通讯作者：
Wakabayashi
中科院分区：
文献类型：
--
作者：
Tamura;Sugihara;Kamegai;Minami;Wakabayashi
大鼠的生长激素（GH）分泌模式存在显著的性别差异。我们之前的研究表明，短期服用药理学剂量的睾酮或双氢睾酮（DHT）会使去卵巢大鼠的生长激素分泌模式雄性化。睾丸激素或DHT与促体轴相互作用的位点被认为是下丘脑。为了深入了解这一现象，我们给成年OVX大鼠以0.01,0.1或1 mg/大鼠的单剂量DHT s.c。测定未麻醉大鼠血液生长激素浓度。在服用三种剂量DHT后6 - 12小时，生长激素的分泌模式显示出与男性相似的分泌模式，即每隔2-3小时出现偶发性爆发，低谷水平低或无法检测到。当对下丘脑内侧基底（ALC）进行前外侧移行时，血液浓度显示不规则的小波动，而不是通常的高爆发，但基础GH浓度明显高于OVX假手术大鼠。二氢睾酮治疗不会引起ALC OVX大鼠的搏动性GH分泌或改变GH浓度。当完整的成年雌性大鼠接受1 mg/大鼠剂量的DHT时，没有诱导雄性样的GH分泌模式。这些结果表明，从前外侧方向到内侧基底下丘脑的神经输入是DHT对OVX大鼠生长激素分泌模式的雄性化作用所必需的，而完整雌性大鼠的雌激素阻止DHT的雄性化作用。
There is a striking sex difference in the pattern of growth hormone (GH) secretion in rats. Our previous studies showed that short‐term administration of pharmacological doses of testosterone or dihydrotestosterone (DHT) masculinized the GH secretory pattern in ovariectomized (OVX) rats. The locus where testosterone or DHT interacts with the somatotropic axis is believed to be the hypothalamus. To obtain insights into this phenomenon, we administered a single dose of DHT s.c. to adult OVX rats at 0.01, 0.1 or 1 mg/rat. Blood GH concentrations were measured in unanaesthetized rats. Six to12 h after the s.c. administration of all three doses of DHT, the GH secretory pattern revealed a male‐like secretory pattern as shown by episodic bursts occurring at 2–3‐h intervals with low or undetectable trough levels. When anterolateral deafferentation of the medial basal hypothalamus (ALC) was performed, the blood concentrations revealed irregularly occurring small fluctuations, instead of the usual high bursts, but the basal GH concentration was significantly higher than that of OVX‐sham‐operated rats. DHT treatment did not elicit pulsatile GH secretion or alter GH concentrations in OVX rats with ALC. When intact adult female rats received DHT at a dose of 1 mg/rat, the male‐like GH secretory pattern was not induced. These results suggest that neural inputs from the anterolateral direction to the medial basal hypothalamus are necessary for the masculinizing effect of DHT on the GH secretory pattern in OVX rats, and that oestrogen in intact female rats prevents the masculinizing effect of DHT.
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大鼠下丘脑生长激素（GH）释放激素基因表达的反馈调节。
DOI：
10.1210/mend-2-3-236
发表时间：
1988
期刊：
Molecular endocrinology (Baltimore, Md.)
影响因子：
--
作者：
Chomczynski,P;Downs,TR;Frohman,LA
通讯作者：
Frohman,LA
雄激素抵抗（睾丸女性化）大鼠的生长激素分泌模式。
影响因子：
4.8
作者：
Millard,WJ;Politch,JA;Martin,JB;Fox,TO
通讯作者：
Fox,TO
影响因子：
4.8
作者：
CHOWENBREED, JA;STEINER, RA;CLIFTON, DK
通讯作者：
CLIFTON, DK
影响因子：
4.1
作者：
ARGENTE, J;CHOWENBREED, JA;CLIFTON, DK
通讯作者：
CLIFTON, DK
成人短期暴露于雌二醇会使大鼠自发和生长激素释放因子刺激的生长激素分泌的男性模式女性化。
影响因子：
4.8
作者：
Painson,JC;Thorner,MO;Krieg,RJ;Tannenbaum,GS
通讯作者：
Tannenbaum,GS