Increased serum androstenedione in adults with autism spectrum conditions
Increased serum androstenedione in adults with autism spectrum conditions
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DOI：
10.1016/j.psyneuen.2011.02.007
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发表时间：
2011-09-01
影响因子：
3.7
通讯作者：
Baron-Cohen, Simon
中科院分区：
文献类型：
--
作者：
Ruta, Liliana;Ingudomnukul, Erin;Baron-Cohen, Simon
分子和行为证据表明性类固醇激素与自闭症谱系障碍（ASC）和/或自闭症特征之间存在关联。产前雄激素水平与自闭症特征相关，并且参与类固醇生成的几个基因与自闭症、Barger综合征和/或自闭症特征相关。此外，据报道，患有自闭症谱系疾病的女性患雄激素相关疾病（如多囊卵巢综合征、多毛症、痤疮和与痤疮相关的癌症）的几率更高。因此，一个关键的问题是，如果血清水平的性腺和肾上腺性类固醇（特别是睾酮，雌二醇，硫酸脱氢表雄酮和雄烯二酮）与ASC的个人升高。这在总共n = 166名参与者的样本中进行了测试。用于激素分析的最终合格样本包括n = 128名参与者，其中n = 58名被诊断为普格综合征或高功能自闭症（33名男性和25名女性），n = 70名为年龄和智商匹配的典型对照（39名男性和31名女性）。ASC诊断（与性别无任何相互作用）强烈预测雄烯二酮水平（p < 0.01），ASC组的血清雄烯二酮水平显著升高（Mann Whitney W = 2677，p = 0.002），女性的排列检验证实了这一结果（排列校正p = 0.02）。这一结果进行了讨论，雄烯二酮的直接前体，并转化为睾酮，二氢睾酮，或雌激素在睾丸激素敏感的组织和器官。(C)2011爱思唯尔有限公司版权所有。
Molecular and behavioural evidence points to an association between sex-steroid hormones and autism spectrum conditions (ASC) and/or autistic traits. Prenatal androgen levels are associated with autistic traits, and several genes involved in steroidogenesis are associated with autism, Asperger Syndrome and/or autistic traits. Furthermore, higher rates of androgen-related conditions (such as Polycystic Ovary Syndrome, hirsutism, acne and hormone-related cancers) are reported in women with autism spectrum conditions. A key question therefore is if serum levels of gonadal and adrenal sex-steroids (particularly testosterone, estradiol, dehydroepiandrosterone sulfate and androstenedione) are elevated in individuals with ASC. This was tested in a total sample of n = 166 participants. The final eligible sample for hormone analysis comprised n = 128 participants, n = 58 of whom had a diagnosis of Asperger Syndrome or high functioning autism (33 males and 25 females) and n = 70 of whom were age- and IQ-matched typical controls (39 males and 31 females). ASC diagnosis (without any interaction with sex) strongly predicted androstenedione levels (p < 0.01), and serum androstenedione levels were significantly elevated in the ASC group (Mann Whitney W = 2677, p = 0.002), a result confirmed by permutation testing in females (permutation-corrected p = 0.02). This result is discussed in terms of androstenedione being the immediate precursor of, and being converted into, testosterone, dihydrotestosterone, or estrogens in hormone-sensitive tissues and organs. (C) 2011 Elsevier Ltd. All rights reserved.