ULTRASTRUCTURAL OBSERVATIONS ON SINUSOIDAL ENDOTHELIAL-CELLS IN CHRONIC ACTIVE HEPATITIS
ULTRASTRUCTURAL OBSERVATIONS ON SINUSOIDAL ENDOTHELIAL-CELLS IN CHRONIC ACTIVE HEPATITIS
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DOI：
10.1111/j.1365-2559.1985.tb02433.x
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发表时间：
1985-01-01
期刊：
影响因子：
6.4
通讯作者：
DESMET, VJ
中科院分区：
文献类型：
--
作者：
BARDADIN, KA;DESMET, VJ
本文研究了12例慢性活动性肝炎肝活检组织的超微结构特征，特别注意内皮细胞。在碎片状坏死和实质性炎症区域，窦状隙内皮细胞显示细胞质肿胀，胞体突出到窦状隙腔中，微胞饮小泡增加，并出现大量致密体。这种细胞类型被称为活性内皮细胞。随后的变化包括高尔基复合体的扩大，粗面内质网的增加，伴随着致密体的减少，出现模糊的外套和形成半桥粒的关系密切的基底膜样材料和网状纤维的空间中的Disse。后者的超微结构特征对应于淋巴结中描述的成纤维网状细胞。活性内皮细胞和成纤维细胞网状细胞可能通过减少血流中的有害物质进入肝实质细胞而在肝实质炎症中起保护作用，并且在窦周纤维化的起始中至关重要。
Ultrastructural features of 12 liver biopsies from patients with chronic active hepatitis were studied, paying particular attention to endothelial cells. In areas of piecemeal necrosis and parenchymal inflammation sinusoidal endothelial cells show swelling of the cytoplasm, protrusion of the cell body into the sinusoidal lumen, increase in micropinocytotic vesicles and appearance of numerous dense bodies. This cell type is termed active endothelial cell. Subsequent changes include enlargement of the Golgi complex, increase of rough endoplasmic reticulum in cytoplasmic processes with concomitant decrease of dense bodies, appearance of a fuzzy coat and formation of hemidesmosomes in close relationship to basement membrane-like material and reticulum fibers in the space of Disse. The latter ultrastructural characteristics correspond to those of fibroblastic reticulum cells described in lymph nodes. Active endothelial cells and fibroblastic reticulum cells may play a protective role in liver parenchymal inflammation by reducing the accessibility of noxious agents from the blood stream to liver parenchymal cells and be crucial in the initiation of perisinusoidal fibrosis.