CD95 and CD95L promote and protect cancer stem cells.
CD95 and CD95L promote and protect cancer stem cells.
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DOI：
10.1038/ncomms6238
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发表时间：
2014-11-04
影响因子：
16.6
通讯作者：
Peter, Marcus E.
中科院分区：
文献类型：
--
作者：
Ceppi, Paolo;Hadji, Abbas;Kohlhapp, Frederick J.;Pattanayak, Abhinandan;Hau, Annika;Liu, Xia;Liu, Huiping;Murmann, Andrea E.;Peter, Marcus E.
CD95(APO-1/Fas)是一种死亡受体，由免疫细胞通过诱导细胞凋亡来杀伤肿瘤细胞。然而，CD95或其配体CD95L从癌细胞中消除会导致CD95R/L消除(DICE)诱导的死亡，这是一种类似于有丝分裂灾难的坏死形式的细胞死亡，提示CD95保护癌细胞免受细胞死亡的影响。我们现在报道，CD95刺激癌细胞或降低miR-200C水平会增加肿瘤干细胞(CSCs)的数量，CSCs对DICE的诱导比非CSC更敏感，同时对CD95介导的细胞凋亡变得不那么敏感。相反，诱导骰子或过表达miR-200C会减少癌症干细胞的数量。我们证明了CSCs和非CSCs对CD95介导的凋亡和DICE具有不同的敏感性，并且通过同时诱导这两种细胞死亡机制可以最大限度地杀灭癌细胞。
CD95 (APO-1/Fas) is a death receptor used by immune cells to kill cancer cells through induction of apoptosis. However, the elimination of CD95 or its ligand, CD95L, from cancer cells results in death induced by CD95R/L elimination (DICE), a type of cell death that resembles a necrotic form of mitotic catastrophe suggesting that CD95 protects cancer cells from cell death. We now report that stimulation of CD95 on cancer cells or reducing miR-200c levels increases the number of cancer stem cells (CSCs), which are more sensitive to induction of DICE than non-CSC, while becoming less sensitive to CD95 mediated apoptosis. In contrast, induction of DICE or overexpression of miR-200c reduces the number of cancer stem cells. We demonstrate that CSCs and non-CSCs have differential sensitivities to CD95-mediated apoptosis and DICE and that killing of cancer cells can be maximized by concomitant induction of both cell death mechanisms.
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影响因子：
64.8
作者：
通讯作者：
--
影响因子：
2.5
作者：
Howe EN;Cochrane DR;Richer JK
通讯作者：
Richer JK
DOI：
10.1073/pnas.1006732107
发表时间：
2010-10-19
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Martin-Villalba, Ana
影响因子：
3.7
作者：
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通讯作者：
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