Microbiological Contamination of Drinking Water Associated with Subsequent Child Diarrhea
Microbiological Contamination of Drinking Water Associated with Subsequent Child Diarrhea
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DOI：
10.4269/ajtmh.15-0274
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发表时间：
2015-11-01
影响因子：
3.3
通讯作者：
Johnston, Richard B.
中科院分区：
文献类型：
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作者：
Luby, Stephen P.;Halder, Amal K.;Johnston, Richard B.
我们采用了一个前瞻性的纵向队列研究，作为项目评估的一部分，以评估饮用水微生物质量和儿童腹泻之间的关系。我们包括孟加拉国农村的50个村庄。在每个村庄，实地工作人员对10个有3岁以下儿童的家庭进行了系统的随机抽样。社区监测员每月访问住户，记录5岁以下儿童在前两天是否腹泻。每三个月，一名研究助理访问该家庭，并要求从用于向儿童提供饮用水的水源或容器中提取水样。实验室技术人员使用薄膜过滤法测量了水样中大肠杆菌的浓度。饮用水中大肠杆菌污染率为59%（2,273/3,833）。杆菌在2年的12，192次每月随访中，有1，156次（9.5%）母亲报告其孩子在前2天内出现腹泻。在多变量一般线性模型中，E.饮用水大肠杆菌污染与儿童腹泻患病率增加有关（患病率比= 1.14，95% CI = 1.05，1.23）。这些数据进一步证明了改善饮用水微生物质量对健康的益处。
We used a prospective, longitudinal cohort enrolled as part of a program evaluation to assess the relationship between drinking water microbiological quality and child diarrhea. We included 50 villages across rural Bangladesh. Within each village field-workers enrolled a systematic random sample of 10 households with a child under the age of 3 years. Community monitors visited households monthly and recorded whether children under the age of 5 years had diarrhea in the preceding 2 days. Every 3 months, a research assistant visited the household and requested a water sample from the source or container used to provide drinking water to the child. Laboratory technicians measured the concentration of Escherichia coli in the water samples using membrane filtration. Of drinking water samples, 59% (2,273/3,833) were contaminated with E. coli. Of 12,192 monthly follow-up visits over 2 years, mothers reported that their child had diarrhea in the preceding 2 days in 1,156 (9.5%) visits. In a multivariable general linear model, the log(10) of E. coli contamination of the preceding drinking water sample was associated with an increased prevalence of child diarrhea (prevalence ratio = 1.14, 95% CI = 1.05, 1.23). These data provide further evidence of the health benefits of improved microbiological quality of drinking water.