DEVELOPMENT OF CARDIAC RATE REGULATION IN PREWEANLING RATS
DEVELOPMENT OF CARDIAC RATE REGULATION IN PREWEANLING RATS
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DOI：
10.1097/00006842-196909000-00003
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发表时间：
1969-01-01
影响因子：
3.3
通讯作者：
REISER, MF
中科院分区：
文献类型：
--
作者：
HOFER, MA;REISER, MF
在4种情况下，通过不受约束的幼犬的轻质导联记录心率：在家里的笼子里，在被实验者抱起的情况下，在一个新的环境中独自生活6分钟，以及对惊吓刺激的反应。幼崽的静息心率在出生后的第二周显示出高交感神经活动；心脏对刺激的反应持续减慢。到20天，低静息率和刺激后心动过速的成人模式已经确立。心率的模式变化伴随着幼年犬的行为快速眼动睡眠和老年犬的自我梳理。自主心脏控制发展的这些不同阶段可能表明早期经历可以不同地塑造成人心脏反应模式的关键时期。
Cardiac rate was recorded by lightweight leads from unrestrained pups under 4 conditions: in the home cage litter situation, while being picked up by the experimenter, during 6 min alone in a novel environment, and in response to a startle stimulus. Resting heart rates in the litter showed evidence of high sympathetic activity during the second week of life; cardiac responses to stimulation were consistently deceleratory. By 20 days, the adult pattern of low resting rates and tachycardia upon stimulation had become established. Patterned changes in cardiac rate accompanied behavioral rapid eye movement sleep in younger pups and self-grooming in older pups. These distinct stages in the development of autonomic cardiac control may indicate critical periods within which early experience can differentially shape the pattern of adult cardiac responses.