Elevated C-reactive protein is a predictor of the development of diabetes in a general Japanese population - The Hisayama Study
Elevated C-reactive protein is a predictor of the development of diabetes in a general Japanese population - The Hisayama Study
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DOI：
10.2337/diacare.28.10.2497
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发表时间：
2005-10-01
期刊：
影响因子：
16.2
通讯作者：
Iida, M
中科院分区：
文献类型：
--
作者：
Doi, Y;Kiyohara, Y;Iida, M
研究设计与方法：根据美国糖尿病协会的禁食标准，将1,759名年龄在40-79岁、无糖尿病的日本受试者按性别分为三组，并进行平均9.0年的前瞻性随访。在男女中，年龄调整后的糖尿病累积发病率随着C反应蛋白水平的升高而显著增加。在多变量分析中，在调整了一些混杂因素(优势比2.63[男性95%可信区间1.2 3~5.651，女性2.2 5[1.0 1~5.0 1])后，C反应蛋白水平最高的人群患糖尿病的风险显著高于最低水平人群。在分层分析中，在没有肥胖或其他与胰岛素抵抗相关的危险因素的受试者和不饮酒的受试者中，这种CRP与糖尿病的相关性更强。结论--我们的研究结果表明，在普通日本人中，升高的CRP浓度是糖尿病的显著预测因素，独立于肥胖和胰岛素抵抗。
OBJECTIVE - We examined the association between high -sensitivity C-reactive protein (CRP) levels and the development of diabetes in a general Japanese population.RESEARCH DESIGN AND METHODS - A total of 1,759 Japanese subjects, aged 40-79 years and without diabetes (according to American Diabetes Association fasting criteria), were stratified into three groups according to CRP tertiles by sex and followed up prospectively for a mean of 9.0 years.RESULTS - During the follow-up, 131 subjects (67 men and 64 women) developed diabetes. In both sexes, the age-adjusted cumulative incidence of diabetes increased significantly as the tertiles of CRP levels increased. In multivariate analyses, the risk of developing diabetes was significantly higher in the highest CRP tertile than in the lowest after adjustment for a number of confounding factors (odds ratio 2.63 [95% CI 1.23-5.651 for men and 2.25 [1.01-5.01] for women). In stratified analyses, this CRP-diabetes association was stronger in subjects without obesity or other risk factors related to insulin resistance and in nondrinking subjects.CONCLUSIONS - Our findings suggest that elevated CRP concentration is a significant predictor of diabetes in the general Japanese population, independent of obesity and insulin resistance.