A prospective study of cigarette smoking and risk of age-related macular degeneration in men
A prospective study of cigarette smoking and risk of age-related macular degeneration in men
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DOI：
10.1001/jama.276.14.1147
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发表时间：
1996-10-09
影响因子：
120.7
通讯作者：
Buring, JE
中科院分区：
文献类型：
--
作者：
Christen, WG;Glynn, RJ;Buring, JE
客观。-为了研究吸烟和发病之间的联系。前瞻性队列研究，AMD平均随访人年为12.2年。共有21157名美国男性医生参与了医生健康研究，他们在基线时没有被诊断为AMD，随访至少7年，并有已知的基线吸烟水平。根据基线时报告的信息，11%为当前吸烟者，39%为既往吸烟者，50%为从不吸烟者。事件AMD，定义为通过病历审查确认的自我报告，在随机化后首次诊断，并负责视力丧失至20/30或更糟。共有268例伴有视力丧失的AMD病例得到证实。在多变量分析中，与从不吸烟者相比，目前每天吸烟20支或更多支的吸烟者患AMD的风险增加（相对风险[RR]，2.46; 95%置信区间[CI]，1.60-3.79）。既往吸烟者患AMD的风险适度升高（RR，1.30; 95%CI，0.99-1.70）。对于目前每天吸烟少于20支的吸烟者，AMD的风险增加了26%（RR，1.26; 95%CI，0.61-2.59）。这些前瞻性数据为吸烟增加患AMD风险的假设提供了支持。
Objective.-To examine the association between cigarette smoking and the incideDesign.-Prospective cohort study with average person-years of follow-up for AMD of 12.2 years.Participants.-A total of 21 157 US male physicians participating in the Physicians' Health Study who did not have a diagnosis of AMD at baseline, were followed for at least 7 years, and had known levels of baseline smoking. Based on information reported at baseline, 11% were current smokers, 39% were past smokers, and 50% were never smokers.Main Outcome Measure.-Incident AMD, defined as a self-report that was confirmed by medical record review, first diagnosed after randomization, and responsible for vision loss to 20/30 or worse.Results.-A total of 268 incident cases of AMD with vision loss were confirmed. In multivariate analysis, current smokers of 20 or more cigarettes per day, compared with never smokers, had an increased risk of AMD (relative risk [RR], 2.46; 95% confidence interval [CI], 1.60-3.79). Past smokers had a modest elevation in risk of AMD (RR, 1.30; 95% CI, 0.99-1.70). For current smokers of fewer than 20 cigarettes per day, there was a nonsignificant 26% increased risk of AMD (RR, 1.26; 95% CI, 0.61-2.59).Conclusions.-These prospective data provide support for the hypothesis that cigarette smoking increases the risk of developing AMD.