Estrogen increases in vivo leptin production in rats and human subjects
Estrogen increases in vivo leptin production in rats and human subjects
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DOI：
10.1677/joe.0.1540285
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发表时间：
1997-08-01
影响因子：
4
通讯作者：
Mori, M
中科院分区：
文献类型：
--
作者：
Shimizu, H;Shimomura, Y;Mori, M
绝经期妇女雌激素的减少会增加身体脂肪。本研究旨在探讨雌激素在体内参与瘦素的产生。在第一项研究中，在大鼠卵巢切除术后2周和8周测量白色脂肪组织中ob基因mRNA的表达。在第二，血清瘦素浓度测定87体重匹配的人类受试者（29名男性，29名绝经前和29名绝经后妇女）的总体脂肪。第三，测定血清瘦素浓度随月经周期的变化。术后8周，去卵巢大鼠皮下和腹膜后白色脂肪组织ob基因表达降低，而去卵巢大鼠肠系膜白色脂肪组织ob基因表达增加。卵巢切除可降低血清瘦素浓度。雌激素补充逆转了卵巢切除对ob基因表达和循环瘦素水平的影响。在人类中，绝经前女性的血清瘦素浓度高于男性，绝经后女性的血清瘦素浓度低于绝经前女性，但仍高于男性。在13例绝经前妇女中，黄体期血清瘦素水平显著高于卵泡期。目前的研究强烈表明，雌激素调节瘦素的生产在大鼠和人类受试者在体内。发现雌激素对ob基因表达的调节存在区域差异。
The decrease in estrogen in menopausal women increases body fat. The present studies were undertaken to investigate the involvement of estrogen in leptin production in vivo. In the first study, expression of ob gene mRNA in white adipose tissue was measured at 2 and 8 weeks after ovariectomy in rats. In the second, serum leptin concentration was measured in total body fat of 87 weight-matched human subjects (29 men, 29 premenopausal and 29 postmenopausal women). In the third, changes in serum leptin concentration with the menstrual cycle were determined. ob gene expression decreased in subcutaneous and retroperitoneal white adipose tissue of ovariectomized rats 8 weeks after the operation, while ovariectomy increased ob gene expression in mesenteric white adipose tissue. Serum leptin concentration was decreased by ovariectomy. Estradiol supplement reversed the effect of ovariectomy on ob gene expression and circulating leptin levels. In humans, serum leptin concentration was higher in premenopausal women than in men, and in postmenopausal women it was lower than in premenopausal women, but still higher than in men. In 13 premenopausal women, serum leptin levels were significantly higher in the luteal phase than in the follicular phase. The present studies strongly indicate that estrogen regulates leptin production in rats and human subjects in viva. Regional variation in the regulation of ob gene expression by estrogen was found.