Neuroradiographic abnormalities in congenital cytomegalovirus infection.
Neuroradiographic abnormalities in congenital cytomegalovirus infection.
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DOI：
10.1016/0887-8994(85)90008-6
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发表时间：
1985-01-01
影响因子：
3.8
通讯作者：
Bell, W E
中科院分区：
文献类型：
--
作者：
Bale, J F Jr;Bray, P F;Bell, W E
为了确定与先天性巨细胞病毒 (CMV) 感染相关的神经放射学异常谱，我们对 15 名有症状感染婴儿的 CT 脑部扫描进行了回顾。 13 名患者的初始 CT 扫描结果异常。异常包括颅内钙化、皮质萎缩、脑室扩大、硬膜下积液、脑孔畸形和多囊性脑软化症。 33%的婴儿存在颅内钙化。此外，15 名婴儿中的 3 名出现进行性脑积水，需要放置脑室腹腔分流术。这些病例说明先天性巨细胞病毒感染会引起多种结构性中枢神经系统病变，并表明进行性脑积水可能是有症状的先天性巨细胞病毒感染的相对常见后果。
To determine the spectrum of neuroradiographic abnormalities associated with congenital cytomegalovirus (CMV) infection, CT brain scans of 15 infants with symptomatic infection were reviewed. The initial CT scans were abnormal in 13 patients. Abnormalities included intracranial calcifications, cortical atrophy, ventricular enlargement, subdural effusions, porencephaly and polycystic encephalomalacia. Intracranial calcifications were present in 33% of the infants. In addition, three of the 15 infants developed progressive hydrocephalus which required ventriculoperitoneal shunt placement. These cases illustrate that congenital CMV infection causes a variety of structural CNS lesions and suggest that progressive hydrocephalus may be a relatively common consequence of symptomatic congenital CMV infection.