Metal acquisition and virulence in Brucella.
Metal acquisition and virulence in Brucella.
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DOI：
10.1017/s1466252312000047
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发表时间：
2012-06
影响因子：
2.5
通讯作者：
Roop RM 2nd
中科院分区：
文献类型：
--
作者：
Roop RM 2nd
与其他细菌类似，布鲁氏菌菌株需要几种生物必需金属才能在体外和体内生存。在哺乳动物宿主中，获得足够水平的这些金属，特别是铁、锰和锌尤其具有挑战性，因为在哺乳动物宿主中，这些微量营养素的固定是先天性和获得性免疫反应的一个有据可查的组成部分。这篇综述描述了布鲁氏菌的金属转运蛋白，已经被证明在这些细菌在实验和自然宿主中的毒力中发挥关键作用。
Similar to other bacteria, Brucella strains require several biologically essential metals for their survival in vitro and in vivo. Acquiring sufficient levels of some of these metals, particularly iron, manganese and zinc, is especially challenging in the mammalian host, where sequestration of these micronutrients is a well-documented component of both the innate and acquired immune responses. This review describes the Brucella metal transporters that have been shown to play critical roles in the virulence of these bacteria in experimental and natural hosts.