Overexpression of neuromedin U is correlated with regional metastasis of head and neck squamous cell carcinoma.
Overexpression of neuromedin U is correlated with regional metastasis of head and neck squamous cell carcinoma.
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Neuromedin U过表达与头颈鳞癌区域转移相关
DOI：
10.3892/mmr.2016.5347
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发表时间：
2016-08
影响因子：
3.4
通讯作者：
Tao Z
中科院分区：
文献类型：
--
作者：
Wang L;Chen C;Li F;Hua QQ;Chen S;Xiao B;Dai M;Li M;Zheng A;Yu D;Hu ZW;Tao Z
对于头颈部鳞状细胞癌（HNSCC）的患者，区域转移是重要的预后因素。神经蛋白U（NMU）是一种分泌的神经肽，由于其有效的子宫收缩活性而命名。本研究的目的是分析NMU在HNSCC区域转移中的重要性。回顾性地总结了从武汉大学（中国武汉）（中国武汉）招募的240名患者的特征。根据材料分析了颈部解剖的阳性速率。使用免疫组织化学分析了人类肿瘤样品中NMU的表达水平。随后，使用组织微测定法研究了NMU的表达，以分析NMU蛋白表达与肿瘤淋巴结转移（TNM）状态之间的关联。在研究样本中，颈部解剖的阳性率为51.4％。与没有转移的肿瘤相比，具有区域转移的原发性肿瘤中NMU的表达水平更高。在晚期肿瘤组织中NMU的蛋白质表达增加。本研究中获得的数据表明，NMU的表达与区域转移和TNM状态相关。 NMU的过表达可能与HNSCC区域转移过程有关，并且可以作为预测HNSCC患者区域转移的新颖而有价值的生物标志物。
Regional metastasis is an important prognostic factor for patients with head and neck squamous cell carcinoma (HNSCC). Neuromedin U (Nmu) is a secreted neuropeptide, named due to its potent uterine contraction-inducing activity. The aim of the present study was to analyze the significance of Nmu in the regional metastasis of HNSCC. The characteristics of 240 patients recruited from the Department of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University (Wuhan, China) were summarized retrospectively. The positive rate of neck dissection was analyzed according to the material. The expression levels of Nmu in human tumor samples were analyzed using immunohistochemistry. Subsequently, the expression of Nmu was investigated using a tissue microassay to analyze the association between Nmu protein expression and Tumor Node Metastasis (TNM) status. The positive rate of neck dissection was 51.4% in the study sample. The expression levels of Nmu in primary tumors with regional metastasis were higher, compared with those without metastasis. There was increased protein expression of Nmu in the advanced tumor tissues. The data obtained in the present study demonstrated that the expression of Nmu was correlated with regional metastasis and TNM status. Overexpression of Nmu may be involved in the process of regional metastasis of HNSCC, and may serve as a novel and valuable biomarker for predicting regional metastasis in patients with HNSCC.