The glutamate receptor subunit GLuR1 is expressed in gonadotrophs of the anterior pituitary and is regulated by gonadal feedback.
The glutamate receptor subunit GLuR1 is expressed in gonadotrophs of the anterior pituitary and is regulated by gonadal feedback.
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作者：
P. Petrusz
An antiserum raised against a synthetic peptide corresponding to the C-terminal amino acid sequence (880-907) of the cloned glutamate receptor protein GluR1 stained gonadotrophic cells in the adenohypophysis of normal male rats. The staining intensity was greatly increased in the hypertrophic gonadotrophs of long-term castrated rats. These results indicate that glutamate may act directly on pituitary gonadotrophs as a neuroendocrine modulator. Furthermore, the expression of GluR1 in gonadotrophs (and thus these cells' ability to respond to glutamate) may be regulated by gonadal factors.
