Hydrogen Sulfide: Its Production, Release and Functions
Hydrogen Sulfide: Its Production, Release and Functions
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DOI：
10.1007/978-3-7091-1550-3_5
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
K. Flannigan;J. Wallace
中科院分区：
文献类型：
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作者：
K. Flannigan;J. Wallace
关于硫化氢(H2S)生理效应的最早描述是在20世纪90年代中期发表的，但几个世纪以来，人们一直在欣赏这种气体介质的治疗益处，方法是沐浴在含硫的温泉中，以及食用能够释放硫化氢的食物，如大蒜。在过去的十年里，随着我们对硫化氢在许多生理和病理生理过程中的贡献的认识的显著增加，人们在药物设计中努力开发这种内源性物质。在本章中，我们回顾了硫化氢在疾病过程中发挥的一些关键作用，设计新型硫化氢释放药物的策略，以及这些药物发挥有益作用的证据。
The first descriptions of physiological effects of hydrogen sulfide (H2S) were published in the mid-1990s, but the therapeutic benefits of this gaseous mediator have been appreciated for centuries, through bathing in sulfide-containing hot springs and through the consumption of foods that can release H2S, such as garlic. In the past decade, with the marked increase in our knowledge about the contribution of H2S to many physiological and pathophysiological processes, efforts have been made to exploit this endogenous substance in drug design. In this chapter we review some of the key roles played by H2S in disease processes, strategies that have been employed to design novel H2S-releasing drugs, and the evidence that these drugs exert beneficial effects.