Convenient synthesis of human calcitonin and its methionine sulfoxide derivative.
Convenient synthesis of human calcitonin and its methionine sulfoxide derivative.
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DOI：
10.1016/s0960-894x(02)00344-x
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发表时间：
2002-08
影响因子：
2.7
通讯作者：
T. Shi;D. Rabenstein
中科院分区：
文献类型：
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作者：
T. Shi;D. Rabenstein
使用Fmoc固相肽合成化学组装人降钙素肽链。裂解试剂H与反式-[Pt（en）2Cl 2]2+以及试剂B、K和R与反式-[Pt（CN）4Cl 2]2−的组合为合成人降钙素及其甲硫氨酸亚砜衍生物提供了方便的方法;上述Pt（IV）氧化剂形成的分子内二硫键基本上是定量的。
The human calcitonin peptide chain was assembled using Fmoc solid-phase peptide synthesis chemistry. The combinations of cleavage Reagent H with trans-[Pt(en)2Cl2]2+and Reagents B, K, and R with trans-[Pt(CN)4Cl2]2−provide convenient methods for the synthesis of human calcitonin and its methionine sulfoxide derivative; the formation of intramolecular disulfide bonds by the above Pt(IV) oxidants is essentially quantitative.