Lower-limb amputation and body weight changes in men
Lower-limb amputation and body weight changes in men
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DOI：
10.1682/jrrd.2014.07.0166
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发表时间：
2015-01-01
影响因子：
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通讯作者：
Boyko, Edward J.
中科院分区：
文献类型：
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作者：
Littman, Alyson J.;Thompson, Mary Lou;Boyko, Edward J.
关于下肢截肢（LLA）和随后的体重变化之间的关系知之甚少。我们进行了一项回顾性队列研究，使用临床和管理数据库，以确定和跟踪759例截肢男性的体重变化（部分足截肢[PFA]，n = 396;经胫骨截肢[TTA]，n = 267;和经股截肢[TFA]，n = 96）和3，790例无截肢频率匹配的男性（5：1）年龄，体重指数，糖尿病和日历年来自太平洋西北部的八个退伍军人事务部医疗保健设施。我们估计并比较了截肢和未截肢男性从基线到随访39个月的纵向百分比体重变化。截肢后2年的体重增加在截肢男性中显著高于未截肢男性，并且在TTA或TFA男性中（增加8%-9%）比PFA男性（增加3%-6%）增加。一般来说，体重增加百分比在2年达到峰值，随后在第三年出现一些体重减轻。这些发现表明，LLA通常伴随着临床上重要的体重增加。未来的研究需要更好地了解体重增加的原因，并确定干预策略，以防止过度体重增加和可能随之而来的有害后果。
Little is known about the relationship between lower-limb amputation (LLA) and subsequent changes in body weight. We conducted a retrospective cohort study using clinical and administrative databases to identify and follow weight changes in 759 males with amputation (partial foot amputation [PFA], n = 396; transtibial amputation [TTA], n = 267; and transfemoral amputation [TFA], n = 96) and 3,790 men without amputation frequency-matched (5:1) on age, body mass index, diabetes, and calendar year from eight Department of Veterans Affairs medical care facilities in the Pacific Northwest. We estimated and compared longitudinal percent weight change from baseline up to 39 mo of follow-up in men with and without amputation. Weight gain in the 2 yr after amputation was significantly more in men with an amputation than without, and in men with a TTA or TFA (8%-9% increase) than in men with a PFA (3%-6% increase). Generally, percent weight gain peaked at 2 yr and was followed by some weight loss in the third year. These findings indicate that LLA is often followed by clinically important weight gain. Future studies are needed to better understand the reasons for weight gain and to identify intervention strategies to prevent excess weight gain and the deleterious consequences that may ensue.