Liquid-based cytology versus conventional papanicolaou smear in an organized screening program -: A prospective Randomized study
Liquid-based cytology versus conventional papanicolaou smear in an organized screening program -: A prospective Randomized study
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DOI：
10.1002/cncr.22953
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发表时间：
2007-10-25
影响因子：
3.4
通讯作者：
Ryd, Walter
中科院分区：
文献类型：
--
作者：
Strander, Bjoern;Andersson-Elistrom, Agneta;Ryd, Walter
背景。本研究的目的是评估液基细胞学（LBC）是否可以进一步提高高标准宫颈癌筛查细胞学。主要终点是当前和后续筛查中的组织病理学高级病变。次要终点是细胞学诊断和样本不足。方法。根据预约时间，女性被随机分配接受传统巴氏涂片或 LBC 涂片检查。其中包括 8810 份常规巴氏涂片和 4674 份 LBC 样本。非典型细胞学评估以及转诊阴道镜检查和治疗均作为常规程序进行。研究结束 8 个月后，从区域数据库中检索组织病理学诊断。平均随唇期为 2 年零 9 个月。 结果。 0.3% 的 LBC 样本中观察到样本不足，而子宫颈抹片检查中的样本不足为 0.7% (P =.002)。细胞学诊断中非良性诊断的总比例分别为 4.5% 和 3.5%（P
BACKGROUND. The objective of this study was to evaluate whether liquid-based cytology (LBC) can improve high-standard cervical cancer screening cytology further. The primary endpoint was histopathologic high-grade lesions in current and subsequent screening rounds. The secondary endpoints were cytologic diagnosis and inadequate samples.METHODS. Women were randomized to smear taking by conventional Papanicolaou (Pap) smear or LBC according to the time of appointment. Eight thousand eight hundred ten conventional Pap smears and 4674 LBC samples were included. Evaluations of atypical cytology and referral to colposcopy and treatment were performed as routine procedures. Histopathologic diagnoses were retrieved from a regional database 8 months after the study was closed. The mean follow-Lip was 2 years and 9 months.RESULTS. inadequate samples were observed in 0.3% of LBC samples versus 0.7% of Pap smears (P =.002). The total fraction of nonbenign diagnoses in cytology was 4.5% versus 3.5%, respectively (P