Comparison of Disease Activity Score (DAS) 28-erythrocyte sedimentation rate and DAS28-C-reactive protein threshold values
Comparison of Disease Activity Score (DAS) 28-erythrocyte sedimentation rate and DAS28-C-reactive protein threshold values
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DOI：
10.1136/ard.2006.054205
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发表时间：
2007-03-01
影响因子：
27.4
通讯作者：
Kamatani, Naoyuki
中科院分区：
文献类型：
--
作者：
Inoue, Eisuke;Yamanaka, Hisashi;Kamatani, Naoyuki
目的：评估类风湿性关节炎患者疾病活动性评分（DAS）28- c反应蛋白（CRP）阈值与das28 -红细胞沉降率（ESR）值对应的缓解、低疾病活动性和高疾病活动性。方法：使用大型观察性研究（类风湿关节炎研究所）数据库对6729例类风湿关节炎患者的DAS28数据进行分析。首先分析DAS28-ESR与DAS28-CRP的关系。其次，使用受试者工作特征（ROC）曲线计算每个阈值的最佳DAS28-CRP权衡值。结果：ESR与CRP的相关系数为0.686，DAS28-ESR与DAS28-CRP的相关系数为0.946，DAS28-ESR与DAS28-CRP的值具有较强的线性关系。缓解、低活动性和高活动性对应的DAS28-CRP阈值分别为2.3、2.7和4.1。随着DAS28值的降低，ROC曲线的敏感性和特异性逐渐降低。结论：本研究显示DAS28-CRP与DAS28-ESR相关性较好，但阈值应重新考虑。由于结果仅来自日本患者，因此比较其他种族人群的DAS28-CRP阈值是必要的。
Objective: To estimate the disease activity score (DAS)28-C-reactive protein (CRP) threshold values that correspond to DAS28-erythrocyte sedimentation rate (ESR) values for remission, low disease activity and high disease activity in patients with rheumatoid arthritis.Methods: DAS28 data were analysed using a large observational study (Institute of Rheumatology Rheumatoid Arthritis) database of 6729 patients with rheumatoid arthritis. Firstly, the relationship between the DAS28-ESR and the DAS28-CRP values was analysed. Secondly, the best DAS28-CRP trade-off values for each threshold were calculated using receiver operating characteristic (ROC) curves.Results: The correlation coefficient of ESR versus CRP was 0.686, whereas that of DAS28-ESR versus DAS28-CRP was 0.946, showing the strong linear relationship between DAS28-ESR and DAS28-CRP values. DAS28-CRP threshold values corresponding to remission, low disease activity and high disease activity were 2.3, 2.7 and 4.1, respectively. The sensitivity and specificity from the ROC curves were gradually reduced as DAS28 values became lower.Conclusions: This study showed that DAS28-CRP and DAS28-ESR were well correlated, but the threshold values should be reconsidered. As the results were derived from only Japanese patients, it is essential to compare DAS28-CRP threshold values in people of other ethnic groups.