Late-onset sensorineural hearing loss due to asymptomatic congenital cytomegalovirus infection retrospectively diagnosed by polymerase chain reaction using preserved umbilical cord.
Late-onset sensorineural hearing loss due to asymptomatic congenital cytomegalovirus infection retrospectively diagnosed by polymerase chain reaction using preserved umbilical cord.
复制标题
使用保存的脐带通过聚合酶链反应回顾性诊断无症状先天性巨细胞病毒感染导致的迟发性感音神经性听力损失。
DOI：
10.1177/0009922810380903
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发表时间：
2011
期刊：
影响因子：
1.6
通讯作者：
et al.
中科院分区：
文献类型：
--
作者：
Ikeno M; et al.
感音神经性耳聋是先天性巨细胞病毒(CMV)感染最常见的神经系统后遗症。在美国，先天性巨细胞病毒感染被认为是15%到25%的儿童听力损失的可能原因。1先天性巨细胞病毒感染的儿童听力损失通常在出生时出现，但可以在几个月甚至几年后发展。虽然有报告称6岁以前出现了迟发性听力损失，2但超过6岁的听力损失却很少有报道。3婴儿以后无症状先天性巨细胞病毒感染患者的病毒学证明并不总是容易的。然而，有几个报告回顾诊断先天性巨细胞病毒感染的聚合酶链式反应(聚合酶链式反应)的脐带或血液储存在格思里卡。3-5我们报告一名9岁起病的男童，其先天性巨细胞病毒感染经聚合酶链式反应证实为先天性巨细胞病毒感染，使用保存的脐带。
Sensorineural hearing loss is the most common neurological sequel of congenital cytomegalovirus (CMV) infection. Congenital CMV infection is considered to be res pon sible for 15% to 25% of hearing loss among children in the United States. 1 Hearing loss in children with congenital CMV infection often presents at birth, but it can develop after months or even years. Although there have been reports on late-onset hearing loss by 6 years of age, 2 the onset of hearing loss beyond 6 years has rarely been reported. 3 Virologic proof is not always easy in patients with asymptomatic congenital CMV infection beyond infancy. However, there have been several reports on retrospective diagnosis of congenital CMV infection by polymerase chain reaction (PCR) for umbilical cord or blood stored on a Guthrie card. 3-5 We report a boy with onset of hearing loss at 9 years of age, in whom congenital CMV infection was retrospectively proven by PCR with the use of preserved umbilical cord.