Assessing shoulder muscle stretch reflexes following breast cancer treatment and postmastectomy breast reconstruction.
Assessing shoulder muscle stretch reflexes following breast cancer treatment and postmastectomy breast reconstruction.
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评估乳腺癌治疗和乳房切除术后乳房重建后的肩部肌肉牵张反射。
DOI：
10.1152/jn.00081.2022
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发表时间：
2023
影响因子：
2.5
通讯作者：
Lipps,DavidB
中科院分区：
文献类型：
--
作者：
Lulic-Kuryllo,Tea;Leonardis,JoshuaM;Momoh,AdeyizaO;Lipps,DavidB
乳房切除术后乳房重建和乳腺癌治疗后肌肉僵硬度发生改变。这些变化背后的确切机制尚不清楚;然而，肌肉牵张反射可能起作用。这项工作研究了乳腺癌幸存者的短（SLR）和长潜伏期（LLR）肩部肌肉拉伸反射。49例接受了乳房切除术后乳房重建的患者，17例接受了放化疗，18例年龄匹配的健康对照者入选。在垂直AB/内收或水平屈曲/伸展扰动期间，记录胸大肌和前、中、后三角肌的锁骨和胸肋区域的肌肉活动，同时参与者保持最小扭矩。量化每块肌肉的SLR和LLR。我们的主要发现是乳房切除术后乳房再造，SLR和LLR在胸大肌锁骨区受损。接受放化疗的个体在胸大肌、前三角肌、中三角肌和后三角肌的锁骨和胸肋区域的牵张反射受损。这些研究结果表明，乳腺癌治疗改变肩肌牵张反射的调节，并可能与手术或非手术损伤的胸筋膜，肌梭，和/或感觉Ia afferends.NEW & NOTEWORTHY肩肌牵张反射可能会受到影响乳房切除术后乳房重建和放化疗。在这里，我们研究了短潜伏期和长潜伏期的肩部肌肉拉伸反射在两个实验后，常见的乳房重建程序和放化疗。我们发现乳腺切除术后乳房再造和放化疗后胸大肌和三角肌牵张反射受损。这些发现表明乳腺癌治疗改变了肩部肌肉拉伸反射的调节。https://jneurophysiol.podbean.com/e/jnp-micro-podcasts-four-questions-tea-lulic-kuryllo-and-david-b-lipps/
Muscle stiffness is altered following postmastectomy breast reconstruction and breast cancer treatment. The exact mechanisms underlying these alterations are unknown; however, muscle stretch reflexes may play a role. This work examined short- (SLR) and long-latency (LLR) shoulder muscle stretch reflexes in breast cancer survivors. Forty-nine patients who had undergone postmastectomy breast reconstruction, 17 who had undergone chemoradiation, and 18 healthy, age-matched controls were enrolled. Muscle activity was recorded from the clavicular and sternocostal regions of the pectoralis major and anterior, middle, and posterior deltoids during vertical ab/adduction or horizontal flex/extension perturbations while participants maintained minimal torques. SLR and LLR were quantified for each muscle. Our major finding was that following postmastectomy breast reconstruction, SLR and LLR are impaired in the clavicular region of the pectoralis major. Individuals who had chemoradiation had impaired stretch reflexes in the clavicular and sternocostal region of the pectoralis major, anterior, middle, and posterior deltoid. These findings indicate that breast cancer treatments alter the regulation of shoulder muscle stretch reflexes and may be associated with surgical or nonsurgical damage to the pectoral fascia, muscle spindles, and/or sensory Ia afferents.NEW & NOTEWORTHYShoulder muscle stretch reflexes may be impacted following postmastectomy breast reconstruction and chemoradiation. Here, we examined short- and long-latency shoulder muscle stretch reflexes in two experiments following common breast reconstruction procedures and chemoradiation. We show impairments in pectoralis major stretch reflexes following postmastectomy breast reconstruction and pectoralis major and deltoid muscle stretch reflexes following chemoradiation. These findings indicate that breast cancer treatments alter the regulation of shoulder muscle stretch reflexes.Listen to this article’s corresponding podcast at https://jneurophysiol.podbean.com/e/jnp-micro-podcasts-four-questions-tea-lulic-kuryllo-and-david-b-lipps/.