ENDOTHELIN-INDUCED COLLAGEN REMODELING IN EXPERIMENTAL PULMONARY-HYPERTENSION
ENDOTHELIN-INDUCED COLLAGEN REMODELING IN EXPERIMENTAL PULMONARY-HYPERTENSION
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DOI：
10.1006/bbrc.1995.2560
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发表时间：
1995-10-24
影响因子：
3.1
通讯作者：
MITSUI, Y
中科院分区：
文献类型：
--
作者：
MANSOOR, AM;HONDA, M;MITSUI, Y
To investigate pathophysiological roles of endothelin-1 (ET-1) in collagen remodeling in pulmonary hypertension, we measured: (a) mRNA expression, concentration, localization of ET-1; (b) changes in types and content of collagen in the lung; (c) and confirmed direct effects of ET-1 on type V collagen metabolism in vascular smooth muscle cells. Monocrotaline-treated rats showed pulmonary hypertension with medial hypertrophy and perivascular fibrosis of pulmonary arteries. At the progressive stage of pulmonary hypertension, both ET-1 levels and its mRNA expression in the lung increased. Total collagen in the lung rose markedly with a higher rate of increase in type V collagen. ET-1, which exists in vascular smooth muscle cells, other perivascular cells and endothelium, stimulated type V collagen production. Our results suggest that local production of ET-1 in the lung contributes to progression of pulmonary hypertension through changes in phenotypes and content of collagen. (C) 1995 Academic Press, Inc.
