Low-cost flexible printed circuit technology based microelectrode array for extracellular stimulation of the invertebrate locomotory system
Low-cost flexible printed circuit technology based microelectrode array for extracellular stimulation of the invertebrate locomotory system
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DOI：
10.1016/j.sna.2011.05.015
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发表时间：
2011-09-10
影响因子：
4.6
通讯作者：
Lal, Amit
中科院分区：
文献类型：
--
作者：
Bozkurt, Alper;Lal, Amit
通过神经和神经肌肉组织的功能性电刺激来控制无脊椎动物的生物控制正在积极探索中。植入式微电极通常被设计用于脊椎动物的慢性长期应用，并受到严格的耐力和分辨率要求。然而，在与无脊椎动物相关的应用中，这些限制可以放宽，以便为大批量市场提供低成本生产。在这项研究中，我们提出了基于柔性印刷电路板（flex-PCB）的植入式神经肌肉刺激电极，解决了相关缺陷，并提出了制造过程中的改进建议。我们能够获得3.18 mC/cm(2)的电荷存储容量和52 k ω的1 kHz阻抗，在柔性pcb电极上镀有100 μ m × 100 μ m的金电极位点。在1 kHz阻抗量级为16 k ω和3 k ω时，氧化铱电沉积和掺杂PSS的PEDOT在微电极上的电化学聚合使电荷存储容量分别提高到38.9和124.3 mC/cm(2)。电流脉冲电压偏移研究也证实了电化学性能的提高。在盐水溶液中的长期浸渍测试支持了柔性pcb电极对昆虫神经电刺激的潜力，同时揭示了PEDOT-PSS涂层在持续高电流密度脉冲下的潜在不稳定性。(C) 2011 Elsevier B.V.版权所有
The biobotic control of invertebrates through functional electrical stimulation of neural and neuromuscular tissue is under active exploration. Implantable microelectrodes are often designed to be used in chronic long term applications in vertebrates and subjected to strict endurance and resolution requirements. However, these constraints can be relaxed in invertebrate-related applications to allow low cost production for high-volume markets. In this study, we propose flexible printed circuit board (flex-PCB) based electrodes for implantable neuromuscular stimulation, address related shortcomings, and suggest modifications in the fabrication process. We were able to obtain a charge storage capacity of 3.18 mC/cm(2) and 1 kHz impedance of 52 k Omega with gold electroplated 100 mu m x 100 mu m electrode sites on the flex-PCB electrodes. The electrodeposition of iridium oxide and electrochemical polymerization of PEDOT with dopant PSS on microelectrodes enhanced the charge storage capacity to 38.9 and 124.3 mC/cm(2) where the 1 kHz impedance magnitude was 16 k Omega and 3 k Omega, respectively. This improvement in electrochemical performance was also corroborated by current pulsed voltage excursion studies. The long term dip test in saline solution supports the potential of flex-PCB electrodes for neural electrostimulation of insects, while revealing potential instability in PEDOT-PSS coatings with continuous high current density pulsing. (C) 2011 Elsevier B.V. All rights reserved.