Noninvasive continuous optical monitoring of absolute cerebral blood flow in critically ill adults.
Noninvasive continuous optical monitoring of absolute cerebral blood flow in critically ill adults.
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DOI：
10.1117/1.nph.5.4.045006
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发表时间：
2018-10
期刊：
影响因子：
5.3
通讯作者：
Yodh AG
中科院分区：
文献类型：
--
作者：
He L;Baker WB;Milej D;Kavuri VC;Mesquita RC;Busch DR;Abramson K;Jiang JY;Diop M;St Lawrence K;Amendolia O;Quattrone F;Balu R;Kofke WA;Yodh AG
我们研究了一种基于时间分辨动态对比增强近红外光谱（DCE-NIRS）和扩散相关光谱（DCS）与半无限头光子传播模型相结合的无创连续监测成人患者绝对脑血流量（CBF）的方案。连续CBF通过DCS血流指数（BFI）与绝对CBF的校准获得，绝对CBF通过间歇静脉注射光学造影剂吲哚菁绿色获得。因此确定了CBF的校准系数（），允许在所有其他时间将DCS BFI转换为绝对血流单位。对急性脑损伤（）患者进行了研究，以确定其稳定性。确定了多个监测日和多个患者的患者平均DCS校准系数，发现在单个监测日的不同时间测量的两个校准系数之间具有良好的一致性。在这种情况下，与XeCT相比，绝对CBF被低估，我们发现的一种影响主要是由于使用了头部的半无限均匀模型。
We investigate a scheme for noninvasive continuous monitoring of absolute cerebral blood flow (CBF) in adult human patients based on a combination of time-resolved dynamic contrast-enhanced near-infrared spectroscopy (DCE-NIRS) and diffuse correlation spectroscopy (DCS) with semi-infinite head model of photon propogation. Continuous CBF is obtained via calibration of the DCS blood flow index (BFI) with absolute CBF obtained by intermittent intravenous injections of the optical contrast agent indocyanine green. A calibration coefficient () for the CBF is thus determined, permitting conversion of DCS BFI to absolute blood flow units at all other times. A study of patients with acute brain injury () is carried out to ascertain the stability of . The patient-averaged DCS calibration coefficient across multiple monitoring days and multiple patients was determined, and good agreement between the two calibration coefficients measured at different times during single monitoring days was found. The patient-averaged calibration coefficient of was applied to previously measured DCS BFI from similar brain-injured patients; in this case, absolute CBF was underestimated compared with XeCT, an effect we show is primarily due to use of semi-infinite homogeneous models of the head.