Safety of high-intensity corneal collagen crosslinking
Safety of high-intensity corneal collagen crosslinking
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DOI：
10.1016/j.jcrs.2013.11.041
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发表时间：
2014-08-01
影响因子：
2.8
通讯作者：
Pallikaris, Aristophanis I.
中科院分区：
文献类型：
--
作者：
Kymionis, George D.;Grentzelos, Michael A.;Pallikaris, Aristophanis I.
目的：评价一种新型高强度角膜胶原交联治疗圆锥角膜的安全性。单位：希腊克里特岛伊拉克利翁克里特岛大学医学院克里特岛Vardinoyiannion眼科研究所。设计:前瞻性介入病例系列。方法：进行性圆锥角膜患者使用一种新的治疗方案，9 mW/cm(2)照射持续10分钟。术前及术后3个月分别评估两组患者的再上皮化率、内皮细胞密度（ECD）、矫正视力（CDVA）、角膜斜度平度数(K)。结果：9例患者（10只眼）入组。所有患者均无术中及术后早期并发症。术后3个月ECD差异无统计学意义（P= 0.169）。CDVA由术前的0.19 logMAR +/- 0.20 （SD）改善至术后3个月的0.10 +/- 0.16 logMAR；但无显著性改善（P= 0.141）。CDVA无眼损线。平均陡K读数从术前的48.04 +/- 2.57屈光度(D)下降到术后3个月的46.51 +/- 2.81屈光度（P= 0.047）；术后平均扁平K读数无显著变化（P= 0.285）。结论：角膜胶原在9 mW/cm(2)辐照下交联10分钟不会引起ECD或术中或术后早期并发症的显著变化。手术后3个月没有患者丢失CDVA线。
PURPOSE: To evaluate the safety of a new high-intensity corneal collagen crosslinking (CXL) treatment protocol for keratoconus.SETTING: Vardinoyiannion Eye Institute of Crete, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece.DESIGN: Prospective interventional case series.METHODS: Patients with progressive keratoconus had CXL using a new treatment protocol with 9 mW/cm(2) irradiance for duration of 10 minutes. The rate of reepithelialization, endothelial cell density (ECD), corrected distance visual acuity (CDVA), and steep and flat keratometry (K) values were evaluated preoperatively and 3 months postoperatively.RESULTS: Nine patients (10 eyes) were enrolled. No intraoperative or early postoperative complications were observed in any patient. The ECD did not change significantly 3 months postoperatively (P=.169). The CDVA improved from 0.19 logMAR +/- 0.20 (SD) preoperatively to 0.10 +/- 0.16 logMAR 3 months postoperatively; however, the improvement did not attain significance (P=.141). No eye lost lines of CDVA. The mean steep K readings decreased significantly from 48.04 +/- 2.57 diopters (D) preoperatively to 46.51 +/- 2.81 D 3 months postoperatively (P=.047); the mean flat K readings did not change significantly postoperatively (P=.285).CONCLUSIONS: Corneal collagen crosslinking at 9 mW/cm(2) irradiance for 10 minutes did not cause significant changes in ECD or intraoperative or early postoperative complications. None patient lost a line of CDVA 3 months after the procedure.