Repetitive transcranial magnetic stimulation for generalised anxiety disorder: a pilot randomised, double-blind, sham-controlled trial
Repetitive transcranial magnetic stimulation for generalised anxiety disorder: a pilot randomised, double-blind, sham-controlled trial
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DOI：
10.1192/bjp.bp.115.168203
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发表时间：
2016-09-01
影响因子：
10.5
通讯作者：
Assaf, Michal
中科院分区：
文献类型：
--
作者：
Diefenbach, Gretchen J.;Bragdon, Laura B.;Assaf, Michal
BackgroundRepetitive transcranial magnetic stimulation（rTMS）holds promise for treating generalised anxiety disorder（GAD）but has only been studied in uncontrolled research.AimsThis is the first randomized controlled trial（clinicaltrials.gov：NCT01659736）to investigate the efficacy and neural correlates of rTMS in GAD.MethodTwenty five participants（active n = 13; sham，n = 12）encountered. rTMS的目标是在右背外侧前额叶皮层（DLPFC，1赫兹，90%静息运动阈值）。ResultsResponse和缓解率较高的活动与假手术组，有显着的组x时间的相互作用焦虑，担心和抑郁症状，有利于积极与假手术。此外，正确的DLPFC激活在决策赌博任务增加在治疗后的积极rTMS只，和神经激活的变化相关的变化显着与担心symptoms.ConclusionsFindings的变化提供了初步证据，rTMS可能会改善GAD症状与修改神经活动的刺激部位。
BackgroundRepetitive transcranial magnetic stimulation (rTMS) holds promise for treating generalised anxiety disorder (GAD) but has only been studied in uncontrolled research.AimsThis is the first randomised controlled trial (clinicaltrials.gov: NCT01659736) to investigate the efficacy and neural correlates of rTMS in GAD.MethodTwenty five participants (active n = 13; sham, n = 12) enrolled. rTMS was targeted at the right dorsolateral prefrontal cortex (DLPFC, 1 Hz, 90% resting motor threshold).ResultsResponse and remission rates were higher in the active v. sham groups and there were significant group x time interactions for anxiety, worry and depressive symptoms, favouring active v. sham. In addition, right DLPFC activation during a decision-making gambling task increased at post-treatment for active rTMS only, and changes in neuroactivation correlated significantly with changes in worry symptoms.ConclusionsFindings provide preliminary evidence that rTMS may improve GAD symptoms in association with modifying neural activity in the stimulation site.