Evolution of hematopoietic stem cell transplantation in Eastern and Western Europe from 1990 to 2003. A report from the EBMT activity survey.
Evolution of hematopoietic stem cell transplantation in Eastern and Western Europe from 1990 to 2003. A report from the EBMT activity survey.
复制标题
1990 年至 2003 年东欧和西欧造血干细胞移植的演变。EBMT 活动调查报告。
作者：
A. Gratwohl;H. Baldomero;B. Labar;J. Apperley;Á. Urbano
造血干细胞移植(HSCT)在过去的十年中得到了迅速的发展。显然，东欧和西欧国家在这一高成本程序方面存在差异。为了更深入地了解与这些差异相关的机制，我们比较了选定的东欧和西欧国家之间异基因和自体HSCT的移植比率(每1000万人的移植数量)，并寻找与它们的差异相关的因素。数据是由欧洲血液和骨髓移植组织(EBMT)在1990年至2003年期间的年度活动调查中获得的。在整个观察期内，东欧国家的自体、异基因和无关的HSCT的移植比率显著较低。20世纪90年代期间，移植比率的迅速上升出现在东欧国家的后期。在过去的三年中，东欧国家的移植比率持续上升，而西欧国家的移植比率则处于平台期。以人均国民总收入衡量的经济因素与低收入国家的移植比率之间存在明显的相关性。团队密度(每1000万人口的团队数量)和移植比率之间也存在明显的相关性。这些数据证明，经济因素只是部分解释了东欧和西欧国家之间移植比率的差异。另一个重要因素似乎是获得治疗程序的机会。这些数据为卫生保健规划提供了依据。
Transplantation of hematopoietic stem cells (HSCT) has seen rapid expansion during the last decade. It is evident that there are differences between eastern and western European countries when this high cost procedure is concerned. In order to obtain more insight into the mechanisms associated with these differences, we compared the transplant rates (number of transplants per 10 million population) for allogeneic and autologous HSCT between selected eastern and western European countries and looked for factors associated with their differences. Data were obtained by the annual European Group for Blood and Marrow Transplantation (EBMT) activity survey for the period from 1990 to 2003. Transplant rates were substantially lower in eastern European countries for autologous, allogeneic, and unrelated HSCT throughout the observation period. The rapid increase in transplant rates during the 1990s occurred later in eastern European countries. Transplant rates continued to rise during the last three years in eastern European countries in contrast to a plateau in transplant rates in western European countries. There was a clear correlation between economic factors, measured as gross national income per capita, and transplant rates for low-income countries. There was also a clear correlation between team density (number of teams per 10 million population) and transplant rates. These data document that economic factors explain the differences in transplant rates between eastern and western European countries only in part. Another important factor seems to be the access to the therapeutic procedure. These data provide a basis for health care planning.