SERUM AND CELL BOUND IGE IN CHRONIC URTICARIA
SERUM AND CELL BOUND IGE IN CHRONIC URTICARIA
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DOI：
10.1111/j.1365-2222.1974.tb01384.x
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发表时间：
1974-01-01
期刊：
影响因子：
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通讯作者：
STANWORTH, DR
中科院分区：
文献类型：
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作者：
GREAVES, MW;PLUMMER, VM;STANWORTH, DR
已通过逆转过敏反应的方法对慢性荨麻疹患者的嗜碱性白细胞结合 IgE 进行了研究。在该反应中，嗜碱性粒细胞结合的 IgE 充当抗原，其存在量与产生最大组胺释放的抗 IgE 浓度成反比。将组胺释放量与抗 IgE 浓度绘制的剂量反应曲线未能揭示荨麻疹受试者与对照受试者相比，嗜碱性粒细胞最大释放的抗 IgE 最佳浓度有任何显着差异，因此表明慢性荨麻疹中嗜碱性粒细胞结合的 IgE 不存在定量异常。然而，与对照组相比，荨麻疹受试者嗜碱性粒细胞抗 IgE 释放的最大组胺量减少，并且这与血清 IgE 浓度无关，因为荨麻疹组的平均血清 IgE 浓度稍高。对两组自发组胺释放和复合 48/80 诱发组胺释放的研究并未揭示组胺储存稳定性或生化组胺释放机制在 48/80 浓度范围内的任何差异。这些结果提出了慢性荨麻疹中嗜碱性粒细胞结合 IgE 定性异常的可能性。
Basophil leucocyte‐bound IgE has been investigated in patients with chronic urticaria by the method of reversed anaphylaxis. In this reaction basophil‐bound IgE behaves as an antigen, the amount present being inversely proportional to the concentration of anti‐IgE producing maximum histamine release. Dose‐response curves in which histamine release was plotted against the concentration of anti‐IgE failed to reveal any substantial difference in the optimum concentration of anti‐IgE for maximum release from basophils of urticarial subjects compared with control subjects, thus suggesting there is no quantitative abnormality of basophil bound IgE in chronic urticaria. However, the magnitude of maximum histamine release by anti‐IgE from basophils of urticarial subjects was reduced compared with controls and this was not related to serum IgE concentrations since the mean serum IgE concentration was slightly higher in the urticaria group. Studies of spontaneous and compound 48/80‐evoked histamine release in the two groups did not reveal any differences in stability of histamine stores or in the biochemical histamine release mechanism over a wide range of concentrations of 48/80. These results raise the possibility of a qualitative abnormality of basophil bound IgE in chronic urticaria.