Fuzhuan Brick Tea Polysaccharides Attenuate Metabolic Syndrome in High-Fat Diet Induced Mice in Association with Modulation in the Gut Microbiota
Fuzhuan Brick Tea Polysaccharides Attenuate Metabolic Syndrome in High-Fat Diet Induced Mice in Association with Modulation in the Gut Microbiota
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DOI：
10.1021/acs.jafc.8b00296
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发表时间：
2018-03-21
影响因子：
6.1
通讯作者：
Liu, Zhonghua
中科院分区：
文献类型：
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作者：
Chen, Guijie;Xie, Minhao;Liu, Zhonghua
越来越多的证据表明,肠道微生物群组成和结构导致代谢综合征(MS)的病理生理学,这提出了一个新的目标治疗食源性女士在这个工作中,我们旨在调查的影响Fuzhuan砖茶多糖(FBTPS)女士和肠道微生物群在高脂肪饮食失调(HFD)喂老鼠和进一步调查是否女士的衰减与肠道微生物群的调制。结果表明，FBTPS干预能显著减轻足量热诱导小鼠的代谢综合征。基于测序结果，FBTPS处理可以增加hfd诱导微生物群的系统发育多样性。FBTPS干预可以显著恢复hfd诱导的丹毒科、coriobacteraceae和Streptococcaceae相对丰度的增加。Spearman相关分析显示，44个关键otu与MS呈负相关或正相关。我们的研究结果表明，FBTPS可以作为一种新的候选药物，通过调节肠道微生物群来预防MS。
An increasing amount of evidence suggests that the gut microbiota composition and structure contribute to the pathophysiology of metabolic syndrome (MS), which has been put forward as a new target in the treatment of diet-induced MS. In this work, we aimed to investigate effects of Fuzhuan brick tea polysaccharides (FBTPS) on MS and gut microbiota dysbiosis in high-fat diet (HFD) fed mice and to further investigate whether its attenuation of MS is related to the modulation of gut microbiota. The results showed that FBTPS intervention could significantly attenuate metabolic syndrome in HFD-induced mice. Based on results of sequencing, FBTPS treatment could increase the phylogenetic diversity of HFD-induced microbiota. FBTPS intervention could significantly restore the HFD-induced increases in relative abundances of Erysipelotrichaceae, Coriobacteriaceae, and Streptococcaceae. Spearman's correlation analysis showed that 44 key OTUs were negatively or positively associated with MS. Our results suggested that FBTPS could serve as a novel candidate for prevention of MS in association with the modulation of gut microbiota.