The effect of stress on craving for methadone depends on the timing of last methadone dose
The effect of stress on craving for methadone depends on the timing of last methadone dose
复制标题
DOI：
10.1016/j.brat.2008.05.013
复制
发表时间：
2008-10-01
影响因子：
4.1
通讯作者：
Trafton, Jodie A.
中科院分区：
文献类型：
--
作者：
Ilgen, Mark;Jain, Anuja;Trafton, Jodie A.
背景资料：本研究以美沙酮维持治疗患者为研究对象，探讨了美沙酮末次给药时间对实验室应激源对美沙酮渴求的影响的调节作用。方法：美沙酮维持治疗患者（N = 41）完成了两个水平的计算机应激操作（低和高压力）在两个不同的日子：（1）在给予他们的标准每日美沙酮剂量之后立即和（2）在接受他们的标准每日剂量之前立即。压力，美沙酮剂量的时间和他们的相互作用的影响进行了检查的自我报告措施的压力和渴望美沙酮。结果：渴望评级不同，根据最后一次美沙酮剂量的时间。美沙酮给药后立即（即，第1天，压力对渴望没有影响（0.12; p = 0.30）。然而，在接受美沙酮剂量之前（即，第2天），高压力对渴望的影响是显著的（1.51; p < 0.001）。讨论：目前的研究结果表明，目前接受美沙酮维持治疗的患者可能特别容易在每天美沙酮给药之前发生与压力相关的复发。爱思唯尔有限公司出版
Background: This study examined the extent to which the timing of last methadone dose moderates the influence of a laboratory stressor on craving for methadone in a sample of methadone maintenance patients.Methods: Methadone maintenance patients (N = 41) completed a Computerized stress manipulation with two levels (low and high stress) on two separate days: (1) immediately following the administration of their standard daily methadone dose and (2) immediately prior to receiving their standard daily dose. The impact of stress, timing of methadone dose and their interaction were examined on self-report measures of stress and craving for methadone.Results: Craving ratings varied according to the timing of last methadone dose. Immediately following methadone dose (i.e., day 1, there was no effect for stress on craving (0.12; p = 0.30). However, prior to receiving methadone dose (i.e., day 2), the high stress effect on craving was significant (1.51; p < 0.001).Discussion: The present findings indicate that patients currently receiving methadone maintenance treatment may be particularly Vulnerable to stress-related relapse immediately prior to daily methadone dosing. Published by Elsevier Ltd.