SCREENING OF SOLID COMMERCIAL PHARMACEUTICALS USING ION MOBILITY SPECTROMETRY
SCREENING OF SOLID COMMERCIAL PHARMACEUTICALS USING ION MOBILITY SPECTROMETRY
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DOI：
10.1021/ac00213a005
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发表时间：
1990-07-15
影响因子：
7.4
通讯作者：
SNYDER, AP
中科院分区：
文献类型：
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作者：
EICEMAN, GA;BLYTH, DA;SNYDER, AP
用离子迁移率光谱仪(IMS)分析在空气中加热到100-200℃的药物固体直接上方产生的蒸气。用IMS/MS对蒸气进行表征，以评估止痛药中成分的空气基常压化学电离。手持式IMS被用来确定基于膜的仪器对大极性分子的常规分析的适用性。7种化合物的迁移率谱可由单个或几个强烈的产物离子峰单独表示。这些药物不存在离子源碎裂，但IMS中涉及离子-分子聚集的复杂行为在某些光谱中显著。迁移率光谱对于每种化合物和单独成分的二元混合物都是明显和可识别的，实际的非处方药产生的迁移率光谱暗示着复合光谱。这项工作代表了首次使用单个组分的光谱来描绘混合物的复杂离子迁移率光谱。这些发现支持IMS的进一步发展，用于此类制剂生产过程中的质量控制和含有止痛药的粉末的常规筛选。
Ion mobility spectrometry (IMS) was used to analyze vapors generated directly above pharmaceutical solids warmed in air to 100-200.degree.C. Vapors were characterized by IMS/mass spectrometry to evaluate the air-based atmospheric pressure chemical ionization of components in analgesic medicines. A hand-held IMS was used to determine the suitability of membrane-based instrumentation for routine analyses of large polar molecules. Mobility spectra for seven compounds could be individually represented by single or a few intense product ion peaks. Ion source fragmentations were nonexistent with these pharmaceuticals but complex behavior in the IMS involving ion-molecule clustering was pronounced in certain spectra. Mobility spectra were distinct and recognizable for each compound and binary mixtures of individual ingredients and actual over-the-counter medicines produced mobility spectra suggestive of composite spectra. This work represents a first delineation of complex ion mobility spectra for mixtures using spectra from individual components. These findings support further development of IMS for use in quality control during manufacture of such preparations and in routine screening of powders containing analgesic pharmaceuticals.