Dengue vaccine: WHO position paper, September 2018-Recommendations
Dengue vaccine: WHO position paper, September 2018-Recommendations
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DOI：
10.1016/j.vaccine.2018.09.063
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发表时间：
2019-08-14
期刊：
影响因子：
5.5
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中科院分区：
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本文介绍了世界卫生组织(WHO)关于登革热疫苗使用的建议，摘录自世卫组织2018年9月发表在《每周流行病学记录》上的登革热疫苗立场文件[1]。这份立场文件取代了2016年7月世卫组织关于第一种获得许可的登革热疫苗--CYD-TDV的立场文件[2]。立场文件提出了2017年11月获得的新证据。使用一种新的血清学分析方法，对临床试验的数据进行了回顾分析，在接种第一剂疫苗之前，根据试验参与者的登革热血清状况对他们进行了分类。这项分析显示，与血清阴性的未接种者相比，血清阴性疫苗接受者患严重登革热的风险更高，同时证实了血清阳性者的长期保护[3]。本文从人群健康的角度对登革热疫苗接种策略提供了修订指南。本文脚注提供了一些核心参考文献，包括评估科学证据质量的评级表和证据-推荐表。根据其就卫生政策事项向会员国提供指导的任务，世卫组织发布了一系列定期更新的关于疫苗和针对具有国际公共卫生影响的疾病的疫苗和疫苗组合的立场文件。这些文件主要涉及大规模免疫方案中疫苗的使用；它们概述了有关疾病和疫苗的基本背景信息，并总结了世卫组织目前在全球范围内使用疫苗的立场。(C)2018年世界卫生组织。爱思唯尔有限公司出版。保留所有权利。
This article presents the World Health Organizations (WHO) recommendations on the use of dengue vaccine excerpted from the WHO position paper on dengue vaccine September 2018, published in the Weekly Epidemiological Record [1]. This position paper replaces the July 2016 WHO position paper concerning the first licensed dengue vaccine, CYD-TDV [2]. The position paper presents new evidence that became available in November 2017. A retrospective analysis of data from clinical trials, using a new serological assay classified trial participants according to their dengue serostatus prior to receipt of the first vaccine dose. The analysis revealed an excess risk of severe dengue in seronegative vaccine recipients compared to seronegative non-vaccinated individuals, while confirming long-term protection in seropositive individuals [3]. The paper provides revised guidance on dengue vaccination strategies from a population health perspective.Footnotes to this paper provide a number of core references including references to grading tables that assess the quality of the scientific evidence, and to the evidence-to-recommendation table. In accordance with its mandate to provide guidance to Member States on health policy matters, WHO issues a series of regularly updated position papers on vaccines and combinations of vaccines against diseases that have an international public health impact. These papers are concerned primarily with the use of vaccines in large-scale immunization programmes; they summarize essential background information on diseases and vaccines, and conclude with WHO's current position on the use of vaccines in the global context. (C) 2018 World Health Organization. Published by Elsevier Ltd. All rights reserved.