Lipooligosaccharides: the principal glycolipids of the neisserial outer membrane.
Lipooligosaccharides: the principal glycolipids of the neisserial outer membrane.
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脂寡糖：奈瑟氏球菌外膜的主要糖脂。
DOI：
10.1093/cid/10.supplement_2.s287
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Apicella,MA
中科院分区：
文献类型：
--
作者：
Griffiss,JM;Schneider,H;Mandrell,RE;Yamasaki,R;Jarvis,GA;Kim,JJ;Gibson,BW;Hamadeh,R;Apicella,MA
细菌的外膜糖脂寄生在没有常规沐浴胆汁酸的粘膜表面，通常缺乏保护肠道细菌脂膜免受扩散的长、亲水和中性多糖。来自这些生物的糖脂被恰当地命名为脂低聚糖。一株奈瑟氏菌产生2到6个脂低聚糖分子，分子数在3,150到7,100之间。不同种类的奈瑟氏菌通常会产生相同mr和表位含量的脂寡糖。低聚糖的差异是观察到的物理异质性的主要原因。低聚糖由(1)部分保守和高度取代的基础低聚糖组成，这些低聚糖在七糖残基上分支；(2)由决定低聚糖长度的残基组成的线形片段；以及(3)类似于鞘糖脂的末端序列。表位表达与物理异质性有关，并受外膜分子环境的影响。血清型表位只存在于特定先生的脂寡糖上，某些脂寡糖调节细菌表面补体的激活，从而调节免疫溶解。
The outer-membrane glycolipids of bacteria that colonize mucosal surfaces that are not routinely bathed by bile acids often lack the long, hydrophilic and neutral polysaccharides that protect the lipid membranes of enteric bacteria from dispersal. The glycolipid from these organisms is properly termed a lipooligosaccharide. A Neisseria strain makes from two to six lipooligosaccharide molecules that range in Mrfrom 3,150 to 7,100. Different species of Neisseria commonly make lipooligosaccharides of identical Mrand epitope content. Differences in oligosaccharides account for most of the observed physical heterogeneity. Oligosaccharides consist of (1) partially conserved and highly substituted basal oligosaccharides that branch at heptose residues; (2) a linear segment consisting ofresidues that determines the length of the oligosaccharide; and (3) terminal sequences that are similar to those of glycosphingolipids. Epitope expression is linked to physical heterogeneity and is modified by the molecular environment of the outer membrane. Serotype epitopes are present only on lipooligosaccharides of a certain Mr. Certain lipooligosaccharides regulate complement activation onto the bacterial surface and, hence, immune lysis.