Age-associated cardiac dysfunction in Drosophila melanogaster
Age-associated cardiac dysfunction in Drosophila melanogaster
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DOI：
10.1161/hh1001.090857
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发表时间：
2001-05-25
影响因子：
20.1
通讯作者：
Reed, JC
中科院分区：
文献类型：
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作者：
Paternostro, G;Vignola, C;Reed, JC
果蝇，黑腹果蝇；是研究衰老的一个有价值的模型/生物体，也是第一个拥有循环系统的生物，它的基因组已经完全测序。然而，人们对苍蝇心形器官在衰老过程中的功能知之甚少。我们已经开发出在成年果蝇体内研究心脏功能的方法。使用两种不同的心血管应激方法(环境温度升高和外部电起搏)，我们发现果蝇的最大心率随着年龄的增长而显著且可重复地降低，这与在老年人中观察到的情况类似。我们还首次描述了幼年果蝇和老年果蝇心脏生理学的其他几个方面，包括与年龄相关的节律紊乱的增加。这些观察结果表明，对老年果蝇心脏功能下降的研究可能会为参与或预防心脏衰老和疾病的基因的全基因组突变筛选提供一个易于遗传处理的模型。
The fruit fly, Drosophila melanogaster; has served as a valuable model/organism for the study of aging and was the first organism possessing a circulatory system to have its genome completely sequenced. However, little is known about the function of the heartlike organ of flies during the aging process. We have developed methods for studying cardiac function in vivo in adult flies. Using 2 different cardiovascular stress methods (elevated ambient temperature and external electrical pacing), we found that maximal heart rate is significantly and reproducibly reduced with aging in Drosophila, analogous to observations in elderly humans. We also describe for the first time several other aspects of the cardiac physiology of young adult and aging Drosophila, including an age-associated increase in rhythm disturbances. These observations suggest that the study of declining cardiac function in aging flies may serve as a genetically tractable model for genome-wide mutational screening for genes that participate in or protect against cardiac aging and disease.