The Kidney in Obesity
The Kidney in Obesity
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DOI：
10.1007/s11906-015-0555-z
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发表时间：
2015-06-01
影响因子：
5.6
通讯作者：
Lurbe, Empar
中科院分区：
文献类型：
--
作者：
Redon, Josep;Lurbe, Empar
体重指数已被发现是第二个最重要的贡献者发展终末期肾病（ESRD）的相对风险后，蛋白尿。肥胖对肾脏的影响包括广泛的范围，从特征性病理学病变到尿白蛋白排泄（UAE）和蛋白尿增加/或肾小球滤过率（GFR）降低。与肥胖相关的肾脏疾病的原因尚不清楚，但出现了两个相关因素。第一个是肥胖相关性肾小球病的存在，第二个是肾脏中的脂肪存款，影响肾脏血液动力学和肾内调节。肥胖和肾损害的联系机制是复杂的，包括血液动力学变化、炎症、氧化应激、细胞凋亡和最终的肾瘢痕形成。保护肾脏损伤需要将联合收割机减肥与适当控制相关的心脏代谢风险因素，高血压，代谢综合征，糖尿病和血脂异常相结合。寻找特定的治疗方法值得未来的研究。
Body mass index has been found to be the second most important contributor to relative risk for developing end state renal disease (ESRD), after proteinuria. The impact of obesity on the kidney includes a wide spectrum, from characteristic pathologic lesions to increment in urinary albumin excretion (UAE) and proteinuria/or decrease in glomerular filtration rate (GFR). The cause of renal disease associated to obesity is not well understood, but two relevant elements emerge. The first is the presence of obesity-related glomerulopathy, and the second is the fat deposit in the kidney with impact on renal haemodynamics and intrarenal regulation. The mechanisms linking obesity and renal damage are complex and include haemodynamic changes, inflammation, oxidative stress, apoptosis, and finally renal scarring. The protection of kidney damage needs to combine weight reduction with the proper control of the cardiometabolic risk factors associated, hypertension, metabolic syndrome, diabetes and dyslipidaemia. The search for specific treatments merits future research.