Pleasure-attenuation of startle is disrupted by lesions of the nucleus accumbens
Pleasure-attenuation of startle is disrupted by lesions of the nucleus accumbens
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DOI：
10.1097/00001756-199605310-00024
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发表时间：
1996-05-31
期刊：
影响因子：
1.7
通讯作者：
Schnitzler, HU
中科院分区：
文献类型：
--
作者：
Koch, M;Schmid, A;Schnitzler, HU
脑桥核（NAC）和杏仁核参与了大脑控制工具性行为的过程。强化有动机和运动两种成分，有必要区分这两个方面。声惊吓反应（ASR）在次级电击器的存在下被衰减。与用于研究奖励机制的其他范例相比，“愉悦衰减惊吓”（PAS）范例通过衰减而不是通过强化反应来指示治疗的奖励特性，从而允许确定治疗的动机影响，而不依赖于其运动刺激效应。在这里，我们报告说，在假手术的动物和大鼠杏仁核病变的阳性条件刺激的存在下，ASR衰减，但在动物轴承6-羟基多巴胺病变的NAC。这些结果表明，NAC的儿茶酚胺能神经支配是重要的行为控制的条件性奖励。
THE nucleus accumbens (NAC) and the amygdala have been implicated in processes by which reinforcers control instrumental behaviour. Reinforcement has both motivational and motor components, and it is necessary to differentiate between these two aspects. The acoustic startle response (ASR) is attenuated in the presence of a secondary reinforcer. In contrast to other paradigms used for investigating mechanisms of reward, the ''pleasure-attenuated startle'' (PAS) paradigm indicates the rewarding properties of a treatment by an attenuation rather than by reinforcement of a response, thus allowing determination of the motivational impact of a treatment independent from its motor stimulating effects. Here, we report that the ASR was attenuated in the presence of a positive conditioned stimulus in sham-operated animals and in rats with lesions of the amygdala, but not in animals bearing 6-hydroxydopamine lesions of the NAC. These findings suggest that the catecholaminergic innervation oi the NAC is important for behavioural control by conditioned reward.