Paraneoplastic antibody during follow-up of a patient with anti-Ri-associated paraneoplastic neurological syndrome
Paraneoplastic antibody during follow-up of a patient with anti-Ri-associated paraneoplastic neurological syndrome
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DOI：
10.1111/j.1600-0404.2008.01102.x
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发表时间：
2009-05-01
影响因子：
3.5
通讯作者：
Rauer, S.
中科院分区：
文献类型：
--
作者：
Stich, O.;Rasiah, C.;Rauer, S.
经典的抗神经元抗体测定在确认神经系统综合征的副肿瘤病因学方面的作用已经得到了很好的确立。然而，在这方面，在副肿瘤性神经综合征（PNS）随访期间抗神经元抗体估计的价值尚不清楚。抗Ri相关PNS患者随访血清样本中抗体浓度的前瞻性分析。使用重组Ri抗原的ELISA半定量估计抗体浓度。循环抗Ri抗体的半定量估计。Ri抗体显示了癌症复发前抗体水平的重新增加，如使用F-氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）所证实的。由于在癌症复发之前随访血清样本中抗神经元抗体浓度的大幅增加，在这种情况下，副肿瘤抗神经元抗体可能代表肿瘤活性的标志物。这些结果保证了进一步的多中心研究，以调查在监测PNS和预测癌症复发的经典抗神经元抗体的系列定量的能力。
The role of classical antineuronal antibody determinations to confirm the paraneoplastic aetiology of a neurological syndrome is well established. However, the value of antineuronal antibody estimation during follow-up of paraneoplastic neurological syndromes (PNS) is not known.Prospective analysis of antibody concentrations in follow-up serum samples from a patient with anti-Ri-associated PNS.Semiquantitative estimation of antibody concentrations with an ELISA using recombinant Ri antigen.Semiquantitative estimation of circulating anti-Ri antibodies demonstrated a renewed increase in antibody levels preceding relapse of the cancer, as confirmed using F-fluorodeoxyglucose positron emission tomography (FDG-PET).This is the first prospective report on serial anti-Ri antibody determinations. As a large increase in antineuronal antibody concentrations in follow-up serum samples preceded relapse of the cancer, paraneoplastic antineuronal antibodies may represent a marker for tumour activity in this case. These results warrant further multicentre studies to investigate the ability of serial quantification of classical antineuronal antibodies in monitoring PNS and in predicting relapse of cancers.