Serum oxidative stress in patients with pulmonary Mycobacterium avium complex disease
Serum oxidative stress in patients with pulmonary Mycobacterium avium complex disease
复制标题
鸟分枝杆菌复合群肺病患者的血清氧化应激
DOI：
10.1016/j.heliyon.2019.e02775
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发表时间：
2019
期刊：
影响因子：
4
通讯作者：
Tatsuno Ichiro
中科院分区：
文献类型：
--
作者：
Wakabayashi Hiroki;Matsuzawa Yasuo;Hayakawa Sho;Irie Tamako;Rikitake Hagino;Tatsuno Ichiro
背景：目前尚不清楚不可治愈的慢性肺部感染（称为肺鸟分枝杆菌复合体（pMAC）病）进行性气道破坏的机制。氧化应激在多种进行性慢性呼吸系统疾病中的参与已有报道。据推测，氧化应激可能参与pMAC疾病气道破坏的进展。患者和方法本研究纳入了28例未经治疗的pMAC患者。通过diacron活性氧代谢产物（d-ROMs）试验定量评价血清氧化应激水平，该试验间接测量血清中过氧化氢的水平。此外，根据ct图像显示的严重程度将患者分为三组。结果所有pMAC患者血清氧化应激水平均超出正常范围（250 ~ 300 U.Carr [Carratelli单位]）（平均值：495.5±102.6 U.Carr；最小-最大值：340 ~ 734 U.Carr）。重症患者血清氧化应激水平明显高于轻症患者（分别为434.6±30.2∶583.4±95.1,p=0.009）。结论pMAC患者血清氧化应激水平升高。这种氧化应激的增加在病情严重的患者中更为明显。
BackgroundThe mechanism of progressive airway destruction in incurable chronic infection of the lung – termed pulmonaryMycobacterium aviumcomplex (pMAC) disease – is currently unknown. The involvement of oxidative stress in a variety of progressive chronic respiratory diseases has been previously reported. It has been hypothesized that oxidative stress may be involved in the progression of airway destruction in pMAC disease.Patients and methodsThe study included 28 untreated patients with pMAC disease. The level of serum oxidative stress was quantitatively evaluated through the diacron reactive oxygen metabolites (d-ROMs) test, which indirectly measures the level of hydroperoxide in the serum. In addition, patients were divided into three groups based on the severity shown in the computed tomographic image.ResultsThe level of serum oxidative stress exceeded the normal range (250–300 U.Carr [Carratelli Units]) in all patients with pMAC disease (mean: 495.5 ± 102.6 U.Carr; minimum–maximum: 340–734 U.Carr). The level of serum oxidative stress in patients with severe disease was significantly higher compared with that observed in patients with mild disease (434.6 ± 30.2 vs. 583.4 ± 95.1, respectively, p=0.009).ConclusionsIn patients with pMAC disease, an elevation was observed in the level of serum oxidative stress. This increase in oxidative stress was more pronounced in patients with severe disease.