Association of polymorphisms in MALAT1 with the risk of esophageal squamous cell carcinoma in a Chinese population
Association of polymorphisms in MALAT1 with the risk of esophageal squamous cell carcinoma in a Chinese population
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MALAT1 多态性与中国人群食管鳞状细胞癌风险的关系
DOI：
10.2147/ott.s191155
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发表时间：
2019-01-01
影响因子：
4
通讯作者：
Cheng, Yufeng
中科院分区：
文献类型：
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作者：
Qu, Yan;Shao, Na;Cheng, Yufeng
目的本研究的主要目的是探讨中国人群中转移相关肺腺癌长链非编码RNA转录本1（MALAT 1）多态性与食管鳞状细胞癌（ESCC）风险的关系。方法对245例食管鳞癌患者和490例年龄、性别匹配的正常对照进行MALAT 1基因4个标签单核苷酸多态性（SNP）（rs3200401 C > T、rs 1122709 C > G、rs664589 C > G和rs619586 A > G）的基因分型。采用卡方检验和Logistic回归分析方法对MALAT 1标签SNP与ESCC的相关性进行分析，<25% was applied to adjust for multiple comparisons. Results We found that rs3200401 C >发现MALAT 1基因的FDR T多态性与ESCC的发病风险显著相关（CT vs CC：校正OR =1.59，95% CI =1.07-2.35，P=0.021; TT vs CC：校正OR =2.27，95% CI =1.04-4.96，P=0.039;显性模型[CT+TT vs CC]：校正OR =1.68，95%CI =1.16-2.43，P=0.006）。分层分析显示，rs3200401 TT和CT/TT基因型与从不饮酒者ESCC发病风险相关（TT vs CC：校正OR =2.34，95%CI =1.02-5.34，P=0.044; CT/TT vs CC：校正OR =1.52，95%CI =1.02-2.26，P=0.041）。然而，与AA基因型相比，MALAT 1 rs619586 GG基因型与ESCC的风险降低相关（GG vs AA：校正OR =0.38，95%CI =0.15-0.99，P=0.049）。除rs619586 GG基因型与AA基因型在饮酒亚组中的比较外，FDR值<0.25，经FDR校正后，结果仍有显著性差异。结论MALAT 1基因rs3200401 C > T多态性与食管鳞癌的发生有关。经FDR校正后，rs619586 A > G多态性与ESCC风险的相关性不显著，提示rs619586 A > G可能是ESCC的保护因子。
Objective The main aim of this study was to investigate the association of polymorphisms in long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) with the risk of esophageal squamous cell carcinoma (ESCC) in a Chinese population. Methods A total of 245 ESCC patients and 490 gender- and age-matched cancer-free controls were genotyped for four tag single nucleotide polymorphisms (SNPs) of MALAT1 (rs3200401 C > T, rs1122709 C > G, rs664589 C > G, and rs619586 A > G). Statistical analyses including chi-squared test and logistic regression were performed to identify the association between the tag SNPs and risk of ESCC, and false discovery rate (FDR) <25% was applied to adjust for multiple comparisons. Results We found that rs3200401 C > T polymorphism of MALAT1 was significantly associated with increased risk of ESCC (CT vs CC: adjusted OR =1.59, 95% CI =1.07–2.35, P=0.021; TT vs CC: adjusted OR =2.27, 95% CI =1.04–4.96, P=0.039; dominant model [CT+TT vs CC]: adjusted OR =1.68, 95% CI =1.16–2.43, P=0.006). In the stratified analysis, rs3200401 TT and CT/TT genotypes were associated with increased risk of ESCC compared with CC genotype in subgroup of never drinking (TT vs CC: adjusted OR =2.34, 95% CI =1.02–5.34, P=0.044; CT/TT vs CC: adjusted OR =1.52, 95% CI =1.02–2.26, P=0.041). However, compared with AA genotype, MALAT1 rs619586 GG was associated with decreased risk of ESCC in ever drinking subgroup (GG vs AA: adjusted OR =0.38, 95% CI =0.15–0.99, P=0.049). The results remained significant after FDR adjustment (FDR value <0.25) except for the comparison between rs619586 GG and AA genotype in ever drinking subgroup. Conclusion Taken together, our findings proposed that polymorphism rs3200401 C > T in MALAT1 gene is associated with increased risk of ESCC. Since the association between rs619586 A > G polymorphism and ESCC risk was not significant after FDR adjustment, there was a minor possibility that rs619586 A > G might be a protective factor for ESCC.