Epidemic multidrug-resistant Acinetobacter baumannii related to European clonal types I and II in Rome (Italy)
Epidemic multidrug-resistant Acinetobacter baumannii related to European clonal types I and II in Rome (Italy)
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DOI：
10.1111/j.1469-0691.2009.02668.x
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发表时间：
2009-04-01
影响因子：
14.2
通讯作者：
Visca, P.
中科院分区：
文献类型：
--
作者：
D'Arezzo, S.;Capone, A.;Visca, P.
对罗马7个重症监护病房（ICU）感染患者18个月内分离的88株多重耐药（MDR）鲍曼不动杆菌菌株进行了分子流行病学和抗生素耐药性遗传基础研究。随机扩增多态性DNA和大酶切分析鉴定出两种优势克隆类型，与欧洲流行克隆I（2型）和II（1型）遗传相关，占A.鲍曼不动杆菌ICU分离株。1型从所有接受调查的ICU中分离出来。在1型和2型分离株中分别检测到2.2和2.5 kb的1类整合子。整合子的结构与以前确定的流行病A的结构相似。来自不同欧洲国家的鲍曼不动杆菌菌株，并提示与欧洲流行性克隆I和II相关的分离株之间的整合子重排/交换。碳青霉烯类耐药与1型分离株中bla（OXA-58）基因的存在相关。结果表明，A.鲍曼不动杆菌1型克隆在医院间传播的潜力很大。
The molecular epidemiology and the genetic basis of antibiotic resistance in 88 multidrug-resistant (MDR) Acinetobacter baumannii strains isolated during 18 months from infected patients in seven intensive care units (ICUs) in Rome were investigated. Random amplified polymorphic DNA and macrorestriction analysis identified two predominant clonal types, genetically related to the European epidemic clones I (type 2) and II (type 1), accounting for 98.9% of A. baumannii ICU isolates. Type 1 was isolated from all ICUs under survey. Class 1 integrons of 2.2 and 2.5 kb were detected in type 1 and type 2 isolates, respectively. The integron structures were similar to those previously determined for epidemic A. baumannii strains from various European countries, and suggestive of integron rearrangement/exchange among isolates related to the European epidemic clones I and II. Carbapenem resistance was associated with the presence of the bla(OXA-58) gene in type 1 isolates. The results indicate that the A. baumannii type 1 clone has a high potential of spreading among hospitals.