Induction of IgA against Haemophilus parainfluenzae antigens in tonsillar mononuclear cells from patients with IgA nephropathy
Induction of IgA against Haemophilus parainfluenzae antigens in tonsillar mononuclear cells from patients with IgA nephropathy
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DOI：
10.1006/clim.2000.4864
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发表时间：
2000-06-01
影响因子：
8.6
通讯作者：
Saito, H
中科院分区：
文献类型：
--
作者：
Fujieda, S;Suzuki, S;Saito, H
大量证据表明，体内和体外IgA的产生在IgA肾病（IgAN）患者中增强。我们已经证实副流感嗜血杆菌抗原（OMHP）外膜的肾小球沉积和IgAN患者血清中HP特异性IgA的存在。在这项研究中，我们研究了OMHP刺激IgAN患者扁桃体单个核细胞（TMC）产生IgA和几种细胞因子。IgAN患者TMC自发产生的总IgA和tgf - β高于慢性扁桃体炎患者（CT） TMC （P < 0.05）。体外OMHP刺激可促进IgAN患者TMC产生hp特异性IgA (P < 0.01)，而CT患者TMC则无此作用。OMHP刺激也增强了IgAN患者TMC产生tgf - β和IL-10 （P < 0.001）。这些结果提示扁桃体HP感染可能参与IgAN的病因学。(C) 2000年学术出版社。
Much evidence suggests that IgA production in vivo and in vitro is enhanced in patients with IgA nephropathy (IgAN). We have demonstrated glomerular deposition of the outer membranes of Haemophilus parainfluenzae (HP) antigens (OMHP) and the presence of HP-specific IgA in the serum of patients with IgAN. In this study, we investigated the production of IgA and several cytokines by tonsillar mononuclear cells (TMC) from IgAN patients induced by stimulation with OMHP. The spontaneous production of total IgA and TGF-beta by TMC from IgAN patients was higher than that by TMC from patients with chronic tonsillitis (CT) (P < 0.05). Stimulation with OMHP in vitro enhanced the production of HP-specific IgA by TMC from IgAN patients (P < 0.01), but not by TMC from CT patients. OMHP stimulation also enhanced the production of TGF-beta and IL-10 by TMC from IgAN patients (P < 0.001). These results suggest that the infection of HP in the tonsil may be involved in the etiology of IgAN. (C) 2000 Academic Press.