The primate lentivirus-encoded Nef protein can regulate several steps of the viral replication cycle
The primate lentivirus-encoded Nef protein can regulate several steps of the viral replication cycle
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DOI：
10.1006/viro.1999.0053
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发表时间：
1999-12-20
期刊：
影响因子：
3.7
通讯作者：
Olive, D
中科院分区：
文献类型：
--
作者：
Collette, Y;Olive, D
灵长类慢病毒编码一种蛋白Nef，这是病毒在宿主中有效复制所必需的。nei的一些生物学活性在体外鉴定可能有助于这种需求在体内，包括受体调节和干扰细胞信号通路。我们表明，HIV和SIV编码的Nef可以在单个病毒复制周期内增强病毒的产生，不仅通过增加病毒的感染性，如先前报道的，而且通过病毒转录和病毒释放的效率起作用。(C)北京：科学出版社.
The primate lentiviruses encode a protein, Nef, which is required for efficient viral replication in their host. Several biological activities of nei identified in vitro may contribute to this requirement in vivo, including receptor modulation and interference with cellular signaling pathways. We show that HIV- and SIV-encoded Nef can enhance virus production within a single viral replication cycle, not only by increasing viral infectivity, as previously reported, but also by acting through the efficiency of viral transcription and of viral release. (C) 1999 Academic Press.