Plasma levels of agouti-related protein are increased in obese men.
Plasma levels of agouti-related protein are increased in obese men.
复制标题
DOI：
10.1210/jcem.86.5.7458
复制
发表时间：
2001-05
期刊：
影响因子：
--
通讯作者：
A. Katsuki;Y. Sumida;E. Gabazza;S. Murashima;Takashi Tanaka;M. Furuta;R. Araki-Sasaki;Y. Hori;K. Nakatani;Y. Yano;Y. Adachi
中科院分区：
文献类型：
--
作者：
A. Katsuki;Y. Sumida;E. Gabazza;S. Murashima;Takashi Tanaka;M. Furuta;R. Araki-Sasaki;Y. Hori;K. Nakatani;Y. Yano;Y. Adachi
为探讨外周血Agouti-related protein（AGRP）水平与各种肥胖参数之间的关系，我们检测了15名肥胖和15名非肥胖男性的AGRP水平，并评估了其与体重指数（BMI）、体脂重量、内脏、皮下和总脂肪面积（通过计算机断层扫描测量）、空腹胰岛素水平、正常血糖高胰岛素钳夹研究期间的葡萄糖输注速率、血清瘦素和血浆α-MSH。肥胖男性血浆AGRP浓度显著高于非肥胖男性（P < 0.01）。单因素分析显示，肥胖男性血浆AGRP水平与BMI、体脂重、皮下脂肪面积呈正相关（BMI：r = 0.732，P < 0.01;体脂重量：r = 0.603，P < 0.02;皮下脂肪面积：r = 0.668，P < 0.01）（BMI：r = 0.839，P < 0.0001;体脂重量：r = 0.818，P < 0.0001;皮下脂肪面积：r = 0.728，P < 0.0001）。在所有男性中，血浆AGRP水平与内脏脂肪面积显着相关（r = 0.478，P < 0.01），总脂肪面积（r = 0.655，P < 0.0001），空腹胰岛素水平（r = 0.488，P < 0.01）、葡萄糖输注率（r =-0.564，P < 0.01）、血清瘦素（r = 0.661，P < 0.0001）、血浆α-MSH（r = 0.556，P < 0.01）。多元回归分析显示，血浆AGRP水平与血浆α-MSH水平呈显著正相关（F = 15.522，r = 0.801，P < 0.03），而与总脂肪面积无关。然而，血浆AGRP水平和血清瘦素水平之间的相关性被认为是依赖于总脂肪面积。简而言之，这些发现表明，AGRP的循环水平在肥胖男性中增加，并且它们与肥胖的各种参数相关。虽然相关性不能证明因果关系，这项研究的结果表明，外周AGRP可能在肥胖的发病机制中发挥作用。
To investigate the relationship between peripheral blood levels of agouti-related protein (AGRP) and various parameters of obesity, we measured the plasma level of AGRP in 15 obese and 15 nonobese men and evaluated its relationship with body mass index (BMI), body fat weight, and visceral, sc, and total fat areas measured by computed tomography, fasting insulin levels, glucose infusion rate during an euglycemic hyperinsulinemic clamp study, serum leptin, and plasma alpha-MSH. Obese men had significantly higher plasma concentrations of AGRP than nonobese men (P < 0.01). Univariate analysis showed that the plasma levels of AGRP are proportionally correlated with BMI, body fat weight, and sc fat area in obese men (BMI: r = 0.732, P < 0.01; body fat weight: r = 0.603, P < 0.02; sc fat area: r = 0.668, P < 0.01) and in all men (BMI: r = 0.839, P < 0.0001; body fat weight: r = 0.818, P < 0.0001; sc fat area: r = 0.728, P < 0.0001). In all men, the plasma levels of AGRP were significantly correlated with the visceral fat area (r = 0.478, P < 0.01), total fat area (r = 0.655, P < 0.0001), fasting insulin level (r = 0.488, P < 0.01), glucose infusion rate (r = -0.564, P < 0.01), serum level of leptin (r = 0.661, P < 0.0001), and the plasma level of alpha-MSH (r = 0.556, P < 0.01). In all subjects, multiple regression analysis showed that the plasma levels of AGRP are significantly (F = 15.522, r = 0.801, P < 0.03) correlated with the plasma levels of alpha-MSH, independently from the total fat area. However, the correlation between plasma levels of AGRP and serum levels of leptin was found to be dependent on the total fat area. In brief, these findings showed that the circulating levels of AGRP are increased in obese men and that they are correlated with various parameters of obesity. Although correlation does not prove causation, the results of this study suggest that peripheral AGRP may play a role in the pathogenesis of obesity.