Comparison of selection pressures on the HA gene of pandemic (2009) and seasonal human and swine influenza A H1 subtype viruses
Comparison of selection pressures on the HA gene of pandemic (2009) and seasonal human and swine influenza A H1 subtype viruses
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DOI：
10.1016/j.virol.2010.06.018
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发表时间：
2010-09-30
期刊：
影响因子：
3.7
通讯作者：
Oshitani, Hitoshi
中科院分区：
文献类型：
--
作者：
Furuse, Yuki;Shimabukuro, Kozue;Oshitani, Hitoshi
2009年人类大流行流感（H1N1）病毒拥有H1亚型的HA基因。 2009 H1N1 病毒的进化过程仍有待确定。我们通过将2009 H1N1病毒与季节性人类和猪病毒进行比较，对HA基因进行了遗传分析。我们分析了116个2009 H1N1病毒的序列，从数据库中获得了1457个季节性H1N1病毒、365个猪H1病毒和1332个2009 H1N1病毒。 2009 H1N1 病毒的选择压力高于猪病毒，与季节性病毒相当。发现位置206和264是正选位点。我们还确定了处于季节性病毒或猪病毒不同选择压力下的位点，这些位点可能与赋予重要的生物学特征有关。 2009年H1N1病毒的H1基因的进化特征与季节性病毒和猪病毒不同。 (C) 2010 Elsevier Inc. 保留所有权利。
The 2009 human pandemic influenza (H1N1) virus possesses the HA gene of the H1 subtype. The evolutionary process of the 2009 H1N1 virus remains to be defined. We performed genetic analyses of the HA gene by comparing the 2009 H1N1 virus with seasonal human and swine viruses.We analyzed sequences of 116 2009 H1N1 viruses, and obtained 1457 seasonal H1N1, 365 swine H1, and 1332 2009 H1N1 viruses from the database. Selection pressure for the 2009 H1N1 virus was higher than that for the swine virus and equivalent to that for the seasonal virus. Positions 206 and 264 were found to be positively selected sites. We also identified sites under different selection pressures from the seasonal or swine virus that may be involved in imparting significant biological characteristics. The evolutionary characteristics of the H1 gene of the 2009 H1N1 virus differed from those of seasonal and swine viruses. (C) 2010 Elsevier Inc. All rights reserved.