Aerobic fitness and body mass index in individuals with schizophrenia: Implications for neurocognition and daily functioning
Aerobic fitness and body mass index in individuals with schizophrenia: Implications for neurocognition and daily functioning
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DOI：
10.1016/j.psychres.2014.08.052
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发表时间：
2014-12-30
影响因子：
11.3
通讯作者：
Sloan, Richard P.
中科院分区：
文献类型：
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作者：
Kimhy, David;Vakhrusheva, Julia;Sloan, Richard P.
先前的报告表明，在健康个体中，低有氧适能（AF）和高体重指数（BMI）预示着神经认知和日常功能较差。目前尚不清楚这些关联是否扩展到以神经认知能力差为特征的疾病，例如精神分裂症。因此，我们比较了精神分裂症患者和非临床对照组的 AF 和 BMI，然后在精神分裂症组中我们检查了 AF、BMI、神经认知和日常功能之间的联系。 32 名精神分裂症患者和 64 名性别和年龄匹配的对照者完成了 AF（以 VO(2)max 为索引）和 BMI 的评估。前者还完成了神经认知、日常功能和身体活动的测量。精神分裂症组表现出明显较低的 AF 和较高的 BMI。在精神分裂症组中，房颤与整体神经认知（r=0.57）以及执行功能、工作记忆、社会认知和处理速度显着相关。分层回归分析表明 AF 占神经认知方差的 22%。此外，房颤与整体日常功能显着相关（r=0.46）。相比之下，体重指数与神经认知呈显着负相关，但与日常功能没有关联。 AF 与体力活动显着相关。作者讨论了增强房颤干预措施改善精神分裂症神经认知和日常功能的潜在用途，以及这些联系背后的假定神经生物学机制，包括脑源性神经营养因子。 (C) 2014 Elsevier Ireland Ltd. 保留所有权利。
Previous reports indicate that among healthy individuals low aerobic fitness (AF) and high body-mass index (BMI) predict poor neurocognition and daily-functioning. It is unknown whether these associations extend to disorders characterized by poor neurocognition, such as schizophrenia. Therefore, we compared AF and BMI in individuals with schizophrenia and non-clinical controls, and then within the schizophrenia group we examined the links between AF, BMI, neurocognition and daily-functioning. Thirty-two individuals with schizophrenia and 64 gender- and age-matched controls completed assessments of AF (indexed by VO(2)max) and BMI. The former also completed measures of neurocognition, daily-functioning and physical activity. The schizophrenia group displayed significantly lower AF and higher BMI. In the schizophrenia group, AF was significantly correlated with overall neurocognition (r=0.57), along with executive functioning, working memory, social cognition, and processing speed. A hierarchical regression analysis indicated that AF accounted for 22% of the neurocognition variance. Furthermore, AF was significantly correlated with overall daily-functioning (r=0.46). In contrast, BMI displayed significant inverse correlations with neurocognition, but no associations to daily-functioning. AF was significantly correlated physical activity. The authors discuss the potential use of AF-enhancing interventions to improve neurocognitive and daily-functioning in schizophrenia, along with putative neurobiological mechanisms underlying these links, including Brain-Derived Neurotrophic Factor. (C) 2014 Elsevier Ireland Ltd. All rights reserved.