How much does phase resetting contribute to event-related EEG abnormalities in schizophrenia?
How much does phase resetting contribute to event-related EEG abnormalities in schizophrenia?
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DOI：
10.1016/j.neulet.2010.06.008
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发表时间：
2010-08-30
影响因子：
2.5
通讯作者：
Liddle, Peter Francis
中科院分区：
文献类型：
--
作者：
Doege, Kathrin;Jansen, Marije;Liddle, Peter Francis
Objective.精神分裂症患者表现出对刺激的低频电生理反应受损，但仍不清楚这些异常是否源于持续振荡的相位重置、新的锁相（诱发）活动或非锁相（诱导）活动。我们的目标是阐明这三个过程中的每一个对精神分裂症信息处理期间神经活动受损的贡献，通过使用不混淆平均刺激后信号的增加与相位重置方法的统计。34名男性精神分裂症患者和34名健康对照者进行了听觉oddball任务。我们将Martinez-Montes等人[18]基于复值小波变换开发的分析程序应用于目标刺激引起的事件相关信号。结果相位锁定δ波（1-4 Hz）和非相位锁定θ波（4- 8Hz）异常最大。δ相重置中度受损，与紊乱症状有关。它还预测了诱发的θ信号。精神分裂症患者的诱发和诱发振荡活动的显著减少表明，不仅参与刺激锁定知觉处理的脑回路的募集减少，而且参与更广泛的处理的脑回路的募集减少，这些处理与刺激的时间锁定不那么紧密。它表明利用持续电活动的能力不足（C）2010 Elsevier爱尔兰有限公司保留所有权利。
Objective. Patients suffering from schizophrenia demonstrate impaired low frequency electrophysiological responses to stimuli, but it remains unclear whether these abnormalities arise from phase resetting of ongoing oscillations, new phase-locked (evoked) activity or non-phase-locked (induced) activity Our goal is to clarify the contribution of each of these three processes to the impairment of neural activity during information processing in schizophrenia, by using statistics that do not confound increases in the mean post-stimulus signal with phase resetting Methods. Thirty-four male schizophrenia patients and 34 healthy matched controls performed an auditory oddball task. We applied the analysis procedure developed by Martinez-Montes et al [18] based on complex-valued wavelet transform to event-related signal elicited by target stimuli. Results The largest abnormalities were found for phase-locked delta (1-4 Hz) and non-phase-locked theta (4-8 Hz). Delta phase resetting was moderately impaired and related to symptoms of disorganization. It also predicted evoked theta signal Conclusion: The substantial reduction of both evoked and induced oscillatory activity in schizophrenia indicates diminished recruitment of brain circuits engaged not only in stimulus-locked perceptual processing but also in more extensive processing less tightly time locked to the stimulus Although reduced phase resetting makes a lesser contribution, it indicates a deficit in the ability to harness ongoing electrical activity (C) 2010 Elsevier Ireland Ltd. All rights reserved.