Brain PET in the diagnosis of Alzheimer's disease.
Brain PET in the diagnosis of Alzheimer's disease.
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DOI：
10.1097/rlu.0000000000000547
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发表时间：
2014-10
影响因子：
10.6
通讯作者：
Subramaniam RM
中科院分区：
文献类型：
--
作者：
Marcus C;Mena E;Subramaniam RM
本文就脑PET在阿尔茨海默病诊断中的作用作一综述。脑FDG-PET上葡萄糖代谢的特征性模式有助于将阿尔茨海默病与其他痴呆原因如额颞叶痴呆和路易体痴呆相鉴别。在适当的临床环境中，淀粉样蛋白脑PET可以排除显著的淀粉样蛋白沉积，从而排除阿尔茨海默病。FDG-PET和淀粉样蛋白PET成像在阿尔茨海默病患者的评估中是有价值的。
The aim of this article was to review the current role of brain PET in the diagnosis of Alzheimer dementia. The characteristic patterns of glucose metabolism on brain FDG-PET can help in differentiating Alzheimer’s disease from other causes of dementia such as frontotemporal dementia and dementia of Lewy body. Amyloid brain PET may exclude significant amyloid deposition and thus Alzheimer’s disease in appropriate clinical setting. FDG-PET and amyloid PET imaging are valuable in the assessment of patients with Alzheimer’s disease.