NR6A1 Allelic Frequencies as an Index for both Miniaturizing and Increasing Pig Body Size
NR6A1 Allelic Frequencies as an Index for both Miniaturizing and Increasing Pig Body Size
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DOI：
10.21873/invivo.12244
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发表时间：
2021-01-01
期刊：
影响因子：
2.3
通讯作者：
Tanimoto, Akihide
中科院分区：
文献类型：
--
作者：
Ijiri, Moe;Lai, Yu-Chang;Tanimoto, Akihide
背景/目的：猪的椎骨数量从19个到23个不等，并与身体大小有关。核受体亚家族A组成员1(NR6A1)被认为是影响猪椎骨数量的重要候选基因。野猪统一有19个脊椎，具有野生型等位基因，而多椎体欧洲商品猪具有突变的等位基因。我们的目的是确定小型化的因素。材料和方法：我们检测了小型猪和三个不同体型的家养猪的椎骨数目和NR6A1基因的多态性。结果：小型猪有19个或更少的椎骨，为野生型NR6A1基因。国内有3个品种的脊椎骨超过21个，而多椎骨固定的大白猪的椎骨数量最多。在中等体型的地方猪中观察到杂合的基因类型，而在欧洲商品猪中观察到纯合子的NR6A1突变。结论：NR6A1可作为猪体小型化和增大化的有用指标。
Background/Aim: The number of vertebrae in swine varies from 19 to 23 and is associated with body size. Nuclear receptor subfamily 6 group A member 1 (NR6A1) is considered a strong candidate for affecting the number of vertebrae in swine. Wild boars, which uniformly have 19 vertebrae, have the wild type allele while multi-vertebrae European commercial pigs have the mutated allele. Our aim was to confirm the factor of the miniaturization. Materials and Methods: We examined vertebrae number and NR6A1 polymorphism in the Microminipig and three domestic breeds that vary in body size. Results: The Microminipig had 19 or less vertebrae and a wild type NR6A1 genotype. Three domestic breeds had more than 21 vertebrae while the largest vertebrae number was observed in multi-vertebrae-fixed Large White. Heterozygous genotypes were observed in the middle-sized indigenous pig while homozygous NR6A1 mutations were observed in European commercial breeds. Conclusion: NR6A1 could be a useful index for both miniaturizing and increasing pig body size.