Binge eating disorder and morbid obesity are associated with lowered mu-opioid receptor availability in the brain
Binge eating disorder and morbid obesity are associated with lowered mu-opioid receptor availability in the brain
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DOI：
10.1016/j.pscychresns.2018.03.006
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发表时间：
2018-06-30
影响因子：
2.3
通讯作者：
Nummenmaa, Lauri
中科院分区：
文献类型：
--
作者：
Joutsa, Juho;Karlsson, Henry K.;Nummenmaa, Lauri
病态肥胖和暴食症（BED）以前都与异常的大脑阿片功能有关。然而，这两种情况在行为上是不同的，这也表明神经递质功能的差异。在这里，我们直接比较了病态肥胖和BED受试者之间的μ阿片受体（莫尔）的可用性。7名BED和19名病态肥胖（非BED）患者以及30名匹配的对照受试者接受了MOR特异性配体[C-11]卡芬太尼的正电子发射断层扫描（PET）。与对照受试者相比，病态肥胖和BED受试者的[C-11]卡芬太尼结合率普遍降低。然而，病态肥胖和BED受试者之间的脑莫尔结合没有显著差异。因此，我们的研究结果表明，有共同的大脑阿片异常行为不同的饮食失调，涉及肥胖。
Both morbid obesity and binge eating disorder (BED) have previously been linked with aberrant brain opioid function. Behaviorally these two conditions are however different suggesting also differences in neurotransmitter function. Here we directly compared mu-opioid receptor (MOR) availability between morbidly obese and BED subjects. Seven BED and nineteen morbidly obese (non-BED) patients, and thirty matched control subjects underwent positron emission tomography (PET) with MOR-specific ligand [C-11]carfentanil. Both subjects with morbid obesity and BED had widespread reduction in [C-11]carfentanil binding compared to control subjects. However, there was no significant difference in brain MOR binding between subjects with morbid obesity and BED. Thus, our results indicate that there is common brain opioid abnormally in behaviorally different eating disorders involving obesity.