Effects of obesity on neuroendocrine, cardiovascular, and immune cell responses to acute psychosocial stress in premenopausal women
Effects of obesity on neuroendocrine, cardiovascular, and immune cell responses to acute psychosocial stress in premenopausal women
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DOI：
10.1016/j.psyneuen.2008.08.019
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发表时间：
2009-02-01
影响因子：
3.7
通讯作者：
Elsenbruch, S.
中科院分区：
文献类型：
--
作者：
Benson, S.;Arck, P. C.;Elsenbruch, S.
目的：分析肥胖与非肥胖绝经前女性对急性心理社会压力的神经内分泌和免疫细胞反应。方法：N = 15 名肥胖（BMI >= 30）和 N = 24（BMI < 30）非肥胖绝经前女性承受公开演讲压力。在公开演讲之前、期间、之后 10 分钟和 45 分钟测量状态焦虑、ACTH、皮质醇和免疫细胞的重新分布。之前分析了血清 hsCRP 和血清 IL-6 水平，并在应激后 45 分钟另外分析了 IL-6。 结果：在应对公开演讲压力时，两组的状态焦虑、血浆 ACTH 和血压均出现显着但相当的增加（所有 p < 0.01；时间效应）。肥胖女性的皮质醇应激反应显着增强（p < 0.05；交互作用）。此外，肥胖女性在承受压力 10 分钟后心率和舒张压显着升高（p < 0.05，t 检验）。公开演讲压力导致 IL-6 浓度显着增加（p < 0.001；时间效应），肥胖女性在压力前后均表现出较高的 IL-6 水平（p < 0.05；群体效应；组间 t 检验：压力前 p < 0.05；压力后 p < 0.01）。肥胖女性的循环白细胞、粒细胞、CD3+细胞和 hsCRP 浓度的基线数量显着较高（组间 t 检验：所有 p < 0.05，但各组在应激诱导的循环白细胞亚群重新分布方面没有差异。结论：我们的数据揭示了肥胖与绝经前女性的慢性低度炎症密切相关。这种促炎症状态以及神经内分泌和炎症反应的改变。心血管压力反应性可能构成将心理压力与肥胖相关的长期健康风险联系起来的机制之一 (C) 2008 Elsevier Ltd. 保留所有权利。
Objective: To analyze the neuroendocrine and immune cell responses to acute psychosocial stress in obese compared to non-obese premenopausal women.Methods: N = 15 obese (BMI >= 30) and N = 24 (BMI < 30) non-obese premenopausal women underwent public speaking stress. State anxiety, ACTH, cortisol, and the redistribution of immune cells were measured before, during, and 10 and 45 min after public speaking. Serum hsCRP and serum IL-6 levels were analyzed before, and IL-6 additionally 45 min after stress.Results: In response to public speaking stress, both groups showed significant but comparable increases in state anxiety, plasma ACTH, and blood pressure (all p < 0.01; time effects). The cortisol stress response was significantly enhanced in obese women (p < 0.05; interaction effect). In addition, heart rate and diastolic blood pressure were significantly higher in obese women 10 min following stress (p < 0.05, t-tests). Public speaking stress led to a significant increase in IL-6 concentrations (p < 0.001; time effect), and obese women displayed higher IL-6 levels both pre- and post-stress (p < 0.05; group effect; between-group t-tests: pre-stress p < 0.05; post-stress p < 0.01). Baseline numbers of circulating leukocytes, granulocytes, CD3+ cells and hsCRP concentration were significantly higher in obese women (between-group t-tests: all p < 0.05, but the groups did not differ in the stress-induced redistribution of circulating leukocyte subpopulations.Conclusions: Our data reveal a strong association of obesity with chronic low-grade inflammation in premenopausal women. This pro-inflammatory state, together with altered neuroendocrine and cardiovascular stress responsiveness, may conceivably constitute one of the mechanisms linking psychological stress and the long-term health risks associated with obesity. (C) 2008 Elsevier Ltd. All rights reserved.